474-74-8 Usage
Description
N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine, also known as Glycolithocholic acid, is a glycine-conjugated form of the secondary bile acid lithocholic acid. It is a metabolite found in human hepatic bile and has been observed to increase in the liver of mice fed a diet supplemented with ursodeoxycholic acid. Additionally, its levels in plasma decrease following subcutaneous administration of PEG-obestatin(Cys10, Cys13), a modified peptide hormone, in lean or diet-induced obese mice. Serum levels of Glycolithocholic acid have also been found to increase with age in children.
Uses
Used in Metabolic Research:
Glycolithocholic acid is used as a metabolite in human hepatic bile for studying its role in various metabolic processes and its potential effects on liver function. It aids in understanding the impact of diet and hormone administration on bile acid metabolism.
Used as a Lithocholic Acid Analog:
Glycolithocholic acid is used as a lithocholic acid analog for inhibiting sialyltransferase, an enzyme involved in the biosynthesis of sialic acids. This application is relevant in research focused on the development of therapeutic agents targeting sialyltransferase for the treatment of various diseases.
Used in Aging Studies:
Glycolithocholic acid is utilized in aging studies to investigate its correlation with age-related changes in children's serum levels. This helps in understanding the role of bile acids in the aging process and their potential implications on health and disease.
Check Digit Verification of cas no
The CAS Registry Mumber 474-74-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 474-74:
(5*4)+(4*7)+(3*4)+(2*7)+(1*4)=78
78 % 10 = 8
So 474-74-8 is a valid CAS Registry Number.
InChI:InChI=1/C26H45NO3/c1-17(5-4-14-27-16-24(29)30)21-8-9-22-20-7-6-18-15-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,27-28H,4-16H2,1-3H3,(H,29,30)/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1
474-74-8Relevant articles and documents
Supramolecular Gels from Conjugates of Bile Acids and Amino Acids and Their Applications
Maity, Mitasree,Maitra, Uday
, p. 1713 - 1720 (2017/04/13)
Hydrogels composed of low molecular weight molecules are gaining increasing importance in biomedical applications. In this work, we report the formation of injectable hydrogels from bile acid–amino acid conjugates. The hydrogelation ability was dependent
Lithocholic acid analogues, new and potent α-2,3-sialyltransferase inhibitors
Chang, Kai-Hsuan,Lee, Lenselot,Chen, Jessica,Li, Wen-Shan
, p. 629 - 631 (2008/02/10)
A new type of noncompetitive α-2,3-sialyltransferase inhibitor has been synthesized; we report the discovery, preparation and inhibitory activity of sixteen lithocholic acid analogues. The Royal Society of Chemistry 2006.
