474023-97-7 Usage
Description
(2S)-amino-4-(tert-butyldimethylsilanyloxy)butanoic acid is a chemical compound with a molecular formula of C10H21NO4Si. It is an amino acid derivative featuring a functional group attached to the alpha carbon. The tert-butyldimethylsilyl (TBDMS) group serves as a protective group in organic synthesis, shielding alcohols and amines from unwanted reactions. This unique structure and reactivity make it a valuable compound for applications in organic synthesis and pharmaceutical research.
Uses
Used in Organic Synthesis:
(2S)-amino-4-(tert-butyldimethylsilanyloxy)butanoic acid is used as a protective agent for alcohols and amines during organic synthesis. The TBDMS group allows chemists to prevent unwanted side reactions, ensuring cleaner reactions and higher yields of desired products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2S)-amino-4-(tert-butyldimethylsilanyloxy)butanoic acid is utilized as a building block for the development of new drugs. Its unique structure and reactivity make it a promising candidate for the synthesis of novel therapeutic agents, potentially leading to the discovery of innovative treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 474023-97-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,4,0,2 and 3 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 474023-97:
(8*4)+(7*7)+(6*4)+(5*0)+(4*2)+(3*3)+(2*9)+(1*7)=147
147 % 10 = 7
So 474023-97-7 is a valid CAS Registry Number.
474023-97-7Relevant articles and documents
INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF
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Paragraph 00125; 00127, (2017/03/14)
The present application relates to a-substituted amino acid compounds of the Formula (I), compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions characterized by or associated with the hypercitrullination of proteins by peptidyl arginine deiminase (PAD) enzymes.
INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF
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Paragraph 0050; 0051; 0052, (2013/10/22)
Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.
Efficient synthesis of sitagliptin phosphate, a novel DPP-IV inhibitor, via a chiral aziridine intermediate
Pan, Xianhua,Li, Xiaojun,Lu, Qingling,Yu, Wansheng,Li, Weijin,Zhang, Qunhui,Deng, Fei,Liu, Feng
, p. 6807 - 6809 (2013/11/19)
Sitagliptin phosphate, a novel DPP-IV inhibitor of T2DM, has been synthesized via 12 linear steps, in an overall yield of 26%. The key step is the coupling reaction of 2,4,5-trifluorophenylmagnesium bromide with a chiral aziridine derivative, which was prepared from l-homo-serine by simple steps.
