474088-40-9

Basic information

• Product Name: (2-amino-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone
• CAS NO: 474088-40-9
• Molecular Weight: 261.708
• Mol File: 474088-40-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-amino-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone(474088-40-9)
• EPA Substance Registry System: (2-amino-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone(474088-40-9)

Safety Data

• Hazardous Substances Data: 474088-40-9(Hazardous Substances Data)

Upstream product

• 3422-01-3 tert-butyl phenylcarbamate 
• 33924-48-0 methyl 5-chloro-2-methoxybenzoate 

Downstream Products

• 221112-51-2 3-Amino-4-(5-chloro-2-methoxyphenyl)quinolin-2(1H)-one 
• 474088-45-4 2-chloro-N-[2-(5-chloro-2-methoxy-benzoyl)-phenyl]-acetamide 

Relevant articles and documents

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.