474116-74-0Relevant articles and documents
Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity
Brady, Stephen F.,Pawluczyk, Joseph M.,Lumma, Patricia K.,Feng, Dong-Mei,Wai, Jenny M.,Jones, Raymond,DeFeo-Jones, Deborah,Wong, Bradley K.,Miller-Stein, Cynthia,Lin, Jiunn H.,Oliff, Allen,Freidinger, Roger M.,Garsky, Victor M.
, p. 4706 - 4715 (2002)
Chemotherapy of prostate cancer with antimitotic agents such as vinblastine and doxorubicin is only marginally effective, due to dose-limiting systemic toxicity. Herein we report the development of peptidyl conjugate 5 of the cytotoxic agent vinblastine (
