474417-23-7

Basic information

• Product Name: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine
• Synonyms: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine;tert-Butyl 4-(thiazol-2-yl)piperazine-1-carboxylate
• CAS NO: 474417-23-7
• Molecular Formula: C₁₂H₁₉N₃O₂S
• Molecular Weight: 269.36
• Product Categories: pharmacetical
• Mol File: 474417-23-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 380.5°C at 760 mmHg
• Flash Point: 183.9°C
• Appearance: /
• Density: 1.209g/cm³
• Vapor Pressure: 5.42E-06mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine(474417-23-7)
• EPA Substance Registry System: 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine(474417-23-7)

Safety Data

• Hazardous Substances Data: 474417-23-7(Hazardous Substances Data)

Usage

General Description

1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine is a chemical compound that belongs to the class of piperazine derivatives. It has a molecular formula C13H20N4O2S and a molecular weight of 300.39 g/mol. 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine is commonly used as an intermediate in the synthesis of pharmaceutical drugs and agrochemicals. It acts as a building block in the production of various biologically active molecules due to its versatile reactivity and functional groups. Additionally, its thiazolyl and tert-butoxycarbonyl groups make it suitable for modifying the physiochemical properties of a target molecule. Overall, 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine plays a key role in medicinal chemistry and drug development.

InChI:InChI=1/C12H19N3O2S/c1-12(2,3)17-11(16)15-7-5-14(6-8-15)10-13-4-9-18-10/h4,9H,5-8H2,1-3H3

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 42270-37-1 1-thiazol-2-yl-piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 77278-40-1 tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate 

Downstream Products

• 492431-13-7 1-(1,3-thiazol-2-yl)piperazine dihydrochloride 
• 623588-36-3 tert-butyl 4-(5-bromo-thiazol-2-yl)piperazine-1-carboxylate 
• 1019637-75-2 tert-butyl 4-(5-methyl-1,3-thiazol-2-yl)-1-piperazinecarboxylate 
• 42270-37-1 1-thiazol-2-yl-piperazine 
• 354587-77-2 tert-butyl 4-(5-formylthiazol-2-yl)piperazine-1-carboxylate 

Relevant articles and documents

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.

Copper-Catalyzed Electrophilic Amination of Heteroarenes via C-H Alumination

A highly efficient Cu-catalyzed electrophilic amination reaction of readily available heteroarenes with O-benzoyl hydroxylamines via a one-pot C-H alumination is reported. The reactions were catalyzed using 1 mol % of CuCl to afford various heteroaryl amines in good to excellent yields. The direct C-H lithiation/transalumination of heteroarenes and catalytic amination sequence can be performed in a single vessel on gram scales.

ACETYLENE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS

The present invention provides Stearoyl CoA Desaturase (SCD) inhibitors, hi particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase 1 (SCD 1) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase (SCD) inhibitors.