475060-43-6

Basic information

• Product Name: TETRAHYDRO-3-(IODOMETHYL)-FURAN
• Synonyms: TETRAHYDRO-3-(IODOMETHYL)-FURAN;3-(Iodomethyl)-tetrahydrofuran;3-(iodomethyl)oxolane;3-(Iodomethyl)
• CAS NO: 475060-43-6
• Molecular Formula: C₅H₉IO
• Molecular Weight: 212.03
• Mol File: 475060-43-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.772
• Vapor Pressure: 0.309mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: TETRAHYDRO-3-(IODOMETHYL)-FURAN(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-3-(IODOMETHYL)-FURAN(475060-43-6)
• EPA Substance Registry System: TETRAHYDRO-3-(IODOMETHYL)-FURAN(475060-43-6)

Safety Data

• Hazardous Substances Data: 475060-43-6(Hazardous Substances Data)

Usage

General Description

Tetrahydro-3-(iodomethyl)-furan is a chemical compound with the molecular formula C5H9IO. It is a halogenated furan derivative, characterized by a furan ring with an attached iodomethyl group. It is commonly used as a building block in organic synthesis and can also be employed as an intermediate in the production of pharmaceuticals and agrochemicals. The iodomethyl group in this compound makes it highly reactive, allowing for a wide range of chemical transformations to take place. TETRAHYDRO-3-(IODOMETHYL)-FURAN is often handled with caution due to its potential reactivity and toxicity.

InChI:InChI=1/C5H9IO/c6-3-5-1-2-7-4-5/h5H,1-4H2

Upstream product

• 65805-36-9 3-(2-iodoethoxy)prop-1-ene 
• 4443-40-7 phthaloylasparic anhydride 
• 184849-49-8 (tetrahydrofuran-3-yl)methyl methanesulfonate 
• 124391-75-9 3-tetrahydrofuranmethanol 
• 15833-63-3 (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 

Downstream Products

• 1080061-17-1 methyl 2-[4-(methylsulfonyl)phenyl]-3-(tetrahydrofuran-3-yl)propanoate 
• 1174229-20-9 triphenyl(tetrahydrofuran-3-ylmethyl)phosphonium iodide 
• 1262512-78-6 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-3-methoxy-5-(tetrahydro-furan-3-ylmethyl)cyclopent-2-enone 
• 625112-74-5 2-(3-chloro-4-methanesulfonyl-phenyl)-3-(tetrahydro-furan-3-yl)-propionic acid 

Relevant articles and documents

Bismuth Compounds in Radical Catalysis: Transition Metal Bismuthanes Facilitate Thermally Induced Cycloisomerizations

The controlled radical chemistry of bismuth compounds is still in its infancy. Further developments are fueled by the properties of these complexes (e.g., low toxicity, high functional group tolerance, low homolytic bond dissociation energies, and reversible homolytic bond dissociations), which are highly attractive for applications in synthetic chemistry. Here we report the first catalytic application of transition metal bismuthanes (i.e. compounds with a Bi–TM bond; TM=transition metal). Using the catalyzed radical cyclo-isomerization of δ-iodo-olefins as a model reaction, characteristics complementary or superior to known B, Mn, Cu, Zn, Sn, and alkali metal reagents are demonstrated (including a different crucial intermediate), establishing transition metal bismuthanes as a new class of (pre-)catalysts for controlled radical reactions.

Pyrazole glucokinase activators

Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.

Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.