4753-68-8 Usage
Description
Furan-2-ylmethanamine hydrochloride is an organic compound with the chemical structure that features a furan ring and an amine group attached to a methyl group. It is a hydrochloride salt, which means it has a hydrochloric acid counterion. furan-2-ylmethanamine hydrochloride is known for its reactivity and utility in various chemical synthesis processes.
Uses
Used in Pharmaceutical Industry:
Furan-2-ylmethanamine hydrochloride is used as a reagent for the synthesis of imides from aldehydes or alcohols and amine hydrochloride salts. It plays a crucial role in the production of various pharmaceutical compounds due to its ability to facilitate the formation of imide rings, which are common structural elements in many drugs.
Used in Chemical Synthesis:
In the field of chemical synthesis, furan-2-ylmethanamine hydrochloride is used as a catalyst to employ copper in the synthesis process. Its presence enhances the efficiency of the reaction and helps in obtaining the desired products with improved yields.
Used in Heterocyclic Chemistry:
Furan-2-ylmethanamine hydrochloride is also utilized in the Mannich aminomethylation of specific heterocyclic compounds, such as 5'',6'',7,''8''-tetrahydro-1''H,3''H-spiro[cyclohexane-1,2''-quinazolin]-4''-one. This application allows the preparation of complex heterocyclic systems with annelated azabicyclic fragments, which are important in the development of novel pharmaceuticals and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 4753-68-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,5 and 3 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4753-68:
(6*4)+(5*7)+(4*5)+(3*3)+(2*6)+(1*8)=108
108 % 10 = 8
So 4753-68-8 is a valid CAS Registry Number.
4753-68-8Relevant articles and documents
Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex
Pandey, Pragati,Bera, Jitendra K.
supporting information, p. 9204 - 9207 (2021/09/20)
A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.
