47546-41-8

Basic information

• Product Name: N¹,N¹-diethyl-N⁴-(2-phenylquinolin-4-yl)pentane-1,4-diamine
• Synonyms: N¹,N¹-diethyl-N⁴-(2-phenylquinolin-4-yl)pentane-1,4-diamine
• CAS NO: 47546-41-8
• Molecular Weight: 361.53
• Mol File: 47546-41-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N¹,N¹-diethyl-N⁴-(2-phenylquinolin-4-yl)pentane-1,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹,N¹-diethyl-N⁴-(2-phenylquinolin-4-yl)pentane-1,4-diamine(47546-41-8)
• EPA Substance Registry System: N¹,N¹-diethyl-N⁴-(2-phenylquinolin-4-yl)pentane-1,4-diamine(47546-41-8)

Safety Data

• Hazardous Substances Data: 47546-41-8(Hazardous Substances Data)

Upstream product

• 140-80-7 5-diethylamino-2-pentylamine 
• 4979-79-7 4-chloro-2-phenylquinoline 

Relevant articles and documents

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

We developed a one-pot, two-stage synthetic route to substituted 4-aminoquinolines involving an imidoylative Sonogashira coupling followed by acid-mediated cyclization. This three-component reaction affords pharmaceutically valuable 4-aminoquinolines in a one-pot procedure from readily available starting materials. The reaction tolerates various substituents on the arene as well as the use of secondary and even primary isocyanides. Additionally, the wide tolerance for functionalized isocyanides allows for the one-pot synthesis of various substituted chloroquine analogues as well as other medicinally relevant products.