47546-42-9Relevant articles and documents
Identification of chemokine receptor CCR4 antagonist
Purandare, Ashok V.,Gao, Aiming,Wan, Honghe,Somerville, John,Burke, Christine,Seachord, Carrie,Vaccaro, Wayne,Wityak, John,Poss, Michael A.
, p. 2669 - 2672 (2007/10/03)
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.