475577-34-5

Basic information

• Product Name: 7-benzyloxy-1-methyl-1H-indole
• Synonyms: 7-benzyloxy-1-methyl-1H-indole
• CAS NO: 475577-34-5
• Molecular Weight: 237.301
• Mol File: 475577-34-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 7-benzyloxy-1-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyloxy-1-methyl-1H-indole(475577-34-5)
• EPA Substance Registry System: 7-benzyloxy-1-methyl-1H-indole(475577-34-5)

Safety Data

• Hazardous Substances Data: 475577-34-5(Hazardous Substances Data)

Upstream product

• 2380-84-9 7-Indolol 
• 100-39-0 benzyl bromide 
• 20289-27-4 7-benzyloxyindole 
• 77-78-1 dimethyl sulfate 
• 553-90-2 Dimethyl oxalate 
• 74-88-4 methyl iodide 

Downstream Products

• 135855-62-8 1-methyl-1H-indol-6-ylamine 
• 941575-87-7 3-(benzofuran-3-yl)-4-(7-benzyloxy-1-methyl-1H-indol-3-yl)pyrrole-2,5-dione 
• 941575-98-0 C₂₀H₁₉NO₄ 

Relevant articles and documents

Ether compound and pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome

The invention relates to an ether compound and a pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome. Specifically, the invention provides a compound as shown in a formula (I), an isomer, a raceme, a prodrug, a solvate, a deuterated substance or a pharmaceutically acceptable salt thereof, and Ar1, Ar2, X, Y and R are defined in the specification.

Replacement of Stoichiometric DDQ with a Low Potential o-Quinone Catalyst Enabling Aerobic Dehydrogenation of Tertiary Indolines in Pharmaceutical Intermediates

A transition-metal/quinone complex, [Ru(phd)3]2+ (phd = 1,10-phenanthroline-5,6-dione), is shown to be effective for aerobic dehydrogenation of 3° indolines to the corresponding indoles. The results show how low potential quinones may be tailored to provide a catalytic alternative to stoichiometric DDQ, due to their ability to mediate efficient substrate dehydrogenation while also being compatible with facile reoxidation by O2. The utility of the method is demonstrated in the synthesis of key intermediates to pharmaceutically important molecules.

Indolyne experimental and computational studies: Synthetic applications and origins of selectivities of nucleophilic additions

Efficient syntheses of 4,5-, 5,6-, and 6,7-indolyne precursors beginning from commercially available hydroxyindole derivatives are reported. The synthetic routes are versatile and allow access to indolyne precursors that remain unsubstituted on the pyrrole ring. Indolynes can be generated under mild fluoride-mediated conditions, trapped by a variety of nucleophilic reagents, and used to access a number of novel substituted indoles. Nucleophilic addition reactions to indolynes proceed with varying degrees of regioselectivity; distortion energies control regioselectivity and provide a simple model to predict the regioselectivity in the nucleophilic additions to indolynes and other unsymmetrical arynes. This model has led to the design of a substituted 4,5-indolyne that exhibits enhanced nucleophilic regioselectivity.