476212-91-6Relevant articles and documents
SAR and x-ray. A new approach combining fragment-based screening and rational drug design: Application to the discovery of nanomolar inhibitors of Src SH2
Lesuisse, Dominique,Lange, Gudrun,Deprez, Pierre,Bénard, Didier,Schoot, Bernard,Delettre, Georges,Marquette, Jean-Pierre,Broto, Pierre,Jean-Baptiste, Véronique,Bichet, Paulette,Sarubbi, Edoardo,Mandine, Eliane
, p. 2379 - 2387 (2007/10/03)
pp60Src is a protein involved in signal transduction and is mainly expressed in neurones, platelets, and osteoclasts. Its precise biological role was recently discovered with the KO experiments by Soriano that gave rise to no other apparent phe