476494-03-8

Basic information

• Product Name: methanesulfonic acid 8-{2-[2-(1-trityl-1H-imidazol-4-yl)-ethylamino]-acetylamino}-naphthalen-2-yl ester
• CAS NO: 476494-03-8
• Molecular Weight: 630.767
• Mol File: 476494-03-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 8-{2-[2-(1-trityl-1H-imidazol-4-yl)-ethylamino]-acetylamino}-naphthalen-2-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 8-{2-[2-(1-trityl-1H-imidazol-4-yl)-ethylamino]-acetylamino}-naphthalen-2-yl ester(476494-03-8)
• EPA Substance Registry System: methanesulfonic acid 8-{2-[2-(1-trityl-1H-imidazol-4-yl)-ethylamino]-acetylamino}-naphthalen-2-yl ester(476494-03-8)

Safety Data

• Hazardous Substances Data: 476494-03-8(Hazardous Substances Data)

Upstream product

• 312937-01-2 2,2,2-trifluoro-N-(2-(1-trityl-1H-imidazol-4-yl)ethyl)acetamide 
• 50580-77-3 2,2,2-trifluoro-N-[2-(1H-imidazol-4-yl)ethyl]acetamide 
• 51-45-6 histamine 
• 195053-92-0 1-(Triphenylmethyl)-4-(2-amino-1-ethyl)imidazole 

Downstream Products

• 476494-04-9 1-[7-((Methanesulfonyl)oxy)naphthyl]-4-[2-(1-triphenylmethyl-4-imidazolyl)-ethyl]-2-piperazinone 
• 254108-76-4 methanesulfonic acid 8-(4-{2-[3-(4-bromo-3-fluoro-benzyl)-3H-imidazol-4-yl]-ethyl}-2-oxo-piperazin-1-yl)-naphthalen-2-yl ester 

Relevant articles and documents

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Compound 1 has been shown to be a dual prenylation inhibitor with FPTase (IC50=2 nM) and GGPTase-I (IC50=95 nM). Analogues of 1, which replaced the cyanophenyl group with various biaryls, led to the discovery of highly potent dual FPTase/GGPTase-I inhibitors. 4-Trifluoromethylphenyl, trifluoropentynyl, and trifluoropentyl were identified as good p-cyano replacements.