4774-14-5 Usage
Description
2,6-Dichloropyrazine is an organic compound characterized by its white powder form. It is a derivative of pyrazine, a heterocyclic compound with two nitrogen atoms in a six-membered ring. The presence of two chlorine atoms at the 2nd and 6th positions of the pyrazine ring gives it unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2,6-Dichloropyrazine is used as a key intermediate in the synthesis of pyrazine and pyridine compounds, which are known as ATR kinase inhibitors. These inhibitors play a crucial role in the development of drugs targeting various diseases, including cancer, by modulating the activity of ATR kinase, a protein involved in DNA damage response and cell cycle regulation.
Used in Chemical Synthesis:
In the field of organic chemistry, 2,6-Dichloropyrazine is utilized in the synthesis of oxacalixarenes containing nitrogen heterocycles. These complex molecular structures have potential applications in various areas, such as supramolecular chemistry, catalysis, and the development of novel materials with specific properties.
Overall, 2,6-Dichloropyrazine is a versatile compound with significant applications in both the pharmaceutical and chemical industries, contributing to the development of new drugs and advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 4774-14-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,7 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4774-14:
(6*4)+(5*7)+(4*7)+(3*4)+(2*1)+(1*4)=105
105 % 10 = 5
So 4774-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H2Cl2N2/c5-3-1-7-2-4(6)8-3/h1-2H
4774-14-5Relevant articles and documents
Preparation method of 2, 6-dichloropyrazine
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Paragraph 0034; 0040; 0053-0061, (2020/04/22)
The invention discloses a preparation method of 2, 6-dichloropyrazine. The method comprises the following steps: taking glycine and glyoxal as raw materials, carrying out ammoniation and cyclization reactions to prepare 2-hydroxypyrazine sodium; and reacting 2-hydroxypyrazine sodium with thionyl chloride under the catalytic action of N,N-diisopropylethylamine to prepare 2-chloropyrazine; wherein pyridine is used as a solvent, and 2-chloropyrazine is subjected to chlorination of chlorine to obtain 2,6-dichloropyrazine. The method has the advantages that the raw material namely glycine is cheapand easily available, and phosphorus oxychloride is not used as a chlorination reagent, so that the generation of organic phosphorus-containing wastewater is greatly reduced, and an effective way is provided for efficient green industrial production of 2, 6-dichloropyrazine.
Studies on Pyrazines. 29. High Regioselective Synthesis of Chloropyrazines from 3-Substituted Pyrazine 1-Oxides
Sato, Nobuhiro,Fujii, Megumi
, p. 1177 - 1180 (2007/10/02)
Reaction of 3-methoxy- or 3-chloropyrazine 1-oxides with refluxing phosphoryl chloride in the presence of amine led to a high regioselective formation of 3-substituted 2-chloropyrazines.In contrast, the use of chloroacetyl chloride instead of phosphoryl chloride enabled different regioselectivity to yield 6-substituted 2-chloropyrazines, particularly 3-methoxycarbonylpyrazine 1-oxide was almost exclusively converted into methyl 6-chloropyrazinecarboxylate under conditions without the amine.