477573-28-7

Basic information

• Product Name: 2H-Indol-2-one, 5-[[(4-fluorophenyl)methyl]sulfonyl]-1,3-dihydro-
• CAS NO: 477573-28-7
• Molecular Formula: C15H12FNO3S
• Molecular Weight: 305.33
• Mol File: 477573-28-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2H-Indol-2-one, 5-[[(4-fluorophenyl)methyl]sulfonyl]-1,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 5-[[(4-fluorophenyl)methyl]sulfonyl]-1,3-dihydro-(477573-28-7)
• EPA Substance Registry System: 2H-Indol-2-one, 5-[[(4-fluorophenyl)methyl]sulfonyl]-1,3-dihydro-(477573-28-7)

Safety Data

• Hazardous Substances Data: 477573-28-7(Hazardous Substances Data)

Upstream product

• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 199328-31-9 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride 
• 1174006-95-1 5-chlorosulfonyl-indol-2-one 

Downstream Products

• 1083096-73-4 (Z)-2-((5-(4-fluorobenzylsulfonyl)-2-oxoindolin-3-ylidene)methyl)-5-(2-(diethylamino)ethyl)-3-methyl-5,6,7,8-tetrahydropyrrolo[3,2-c]azepin-4(1H)-one 
• 1083096-71-2 (Z)-2-((5-(4-fluorobenzylsulfonyl)-2-oxoindolin-3-ylidene)methyl)-3-methyl-5-(2-morpholinoethyl)-5,6,7,8-tetrahydropyrrolo[3,2-c]azepin-4(1H)-one 
• 1083096-67-6 2-[5-(4-fluoro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-pyrrolidin-1-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one 
• 1083096-69-8 (Z)-2-((5-(4-fluorobenzylsulfonyl)-2-oxoindolin-3-ylidene)methyl)-3-methyl-5-(2-(piperidin-1-yl)ethyl)-5,6,7,8-tetrahydropyrrolo[3,2-c]azepin-4(1H)-one 
• 1083096-75-6 (R,Z)-2-((5-(4-fluorobenzylsulfonyl)-2-oxoindolin-3-ylidene)methyl)-5-(2-hydroxy-3-morpholinopropyl)-3-methyl-5,6,7,8-tetrahydropyrrolo[3,2-c]azepin-4(1H)-one 

Relevant articles and documents

PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF

The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, espe

5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to certain 5-aralkylsulfonyl-3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular met kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.