477573-39-0Relevant articles and documents
Rapid improvement of a reductive sulfonylation using design of experiment methods
Chen, Jiong Jack,Nugent, Thomas C.,Lu, Cuong V.,Kondapally, Sudharani,Giannousis, Peter,Wang, Ying,Wilmot, Jeremy T.
, p. 313 - 317 (2003)
Sulfone 2 was initially prepared using a zinc-mediated one-pot coupling procedure. A traditional sodium sulfite-mediated two-pot procedure was found to eliminate a major impurity, yet modest yields prevailed. Design of experiment methods with the aid of a basic parallel synthesizer rapidly led to a high-yielding one-pot process.
PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF
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Page/Page column 91, (2010/04/23)
The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, espe
Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
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Page/Page column 22, (2010/02/08)
The present invention is directed to a class indolinone compounds, hexahydro-cyclohepta-pyrrole oxindoles, which are useful as protein kinase inhibitors.