477775-57-8 Usage
Description
2,5,8,11,14,17,20-Heptaoxadocosan-22-ol, methanesulfonate is a complex organic molecule with a long hydrophilic PEG (polyethylene glycol) chain and a methanesulfonate group. The PEG chain enhances solubility in aqueous media, while the methanesulfonate group acts as a good leaving group for nucleophilic substitution reactions.
Uses
Used in Pharmaceutical Industry:
2,5,8,11,14,17,20-Heptaoxadocosan-22-ol, methanesulfonate is used as a PEG linker for drug conjugation. The hydrophilic PEG spacer increases the solubility of the drug in aqueous media, improving its pharmacokinetic properties and reducing the potential for immunogenicity. The methanesulfonate group serves as a reactive handle for attaching the drug molecule through nucleophilic substitution reactions.
Used in Drug Delivery Systems:
In the field of drug delivery, 2,5,8,11,14,17,20-Heptaoxadocosan-22-ol, methanesulfonate is used as a component in the design of targeted drug delivery systems. The PEG chain can be functionalized with targeting ligands, allowing for specific binding to receptors overexpressed on cancer cells or other diseased tissues. This targeted approach can enhance the therapeutic efficacy of the drug and reduce off-target side effects.
Used in Organic Synthesis:
2,5,8,11,14,17,20-Heptaoxadocosan-22-ol, methanesulfonate can also be utilized in organic synthesis as a versatile building block for the creation of more complex molecules. The PEG chain and methanesulfonate group can be further modified or used as starting points for the synthesis of various bioactive compounds, pharmaceuticals, or materials with specific properties.
Check Digit Verification of cas no
The CAS Registry Mumber 477775-57-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,7,7,7 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 477775-57:
(8*4)+(7*7)+(6*7)+(5*7)+(4*7)+(3*5)+(2*5)+(1*7)=218
218 % 10 = 8
So 477775-57-8 is a valid CAS Registry Number.
477775-57-8Relevant articles and documents
Minimalistic β-sitosterol based designer surfactants for efficient cross-coupling in water
Fabris, Fabrizio,Frigatti, Davide,Lorenzetto, Tommaso,Scarso, Alessandro
supporting information, (2022/03/16)
In this contribution, we report about the synthesis, the aggregation properties and their application in cross-coupling catalysis of two new designer surfactants comprising a rigid hydrophobic portion based on β-sitosterol directly linked by an etheric bond to methyl polyoxoethylene chains. The proposed amphiphilic compounds represent a minimalistic approach with respect to the Lipshutz's third generation designer surfactant Nok. The amphiphiles displayed improved chemical stability, shorter synthesis, and good properties in Pd-catalyzed cross-coupling reactions in water under mild conditions, as compared with other neutral commercially available surfactants.
triAZOLOtriAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS
-
Page/Page column 54, (2020/01/24)
The present invention provides triazolotriazine derivatives of formula (1) as A2A receptor antagonists. Compounds of formula (1) and pharmaceutical compositions including the compounds can be used for the treatment of disorders related to A2A receptor hyperfunctioning, such as certain types cancers. Compounds of formula (1) and methods of preparing the compounds are disclosed in the invention.
NALOXEGOL OXALATE AND SOLID DISPERSION THEREOF
-
, (2018/06/12)
The present invention relates to solid dispersion of Naloxegol oxalate. Further, the present invention relates to an improved process for Naloxegol oxalate and intermediates thereof.
