478081-98-0 Usage
Description
Acetamide, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylis a chemical compound that plays a significant role in the synthesis of pharmaceuticals. It is characterized by its unique molecular structure, which includes a cyanopyrazolo[1,5-a]pyrimidin-5-yl group attached to a phenyl ring, with an ethyl group connected to the amide moiety. Acetamide, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylis known for its potential applications in the development of therapeutic agents.
Uses
1. Used in Pharmaceutical Synthesis:
Acetamide, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylis used as an intermediate in the synthesis of Zaleplon (Z145000), a selective non-benzodiazepine GABAA receptor agonist. Acetamide, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylis specifically designed for the management and treatment of insomnia, offering a sedative-hypnotic effect to help patients achieve a restful sleep.
2. Used in the Treatment of Insomnia:
In the pharmaceutical industry, Acetamide, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylis utilized as a key component in the development of Zaleplon, a medication that targets GABAA receptors in the brain. By modulating these receptors, Zaleplon helps to induce sleep and alleviate the symptoms of insomnia, making it a valuable application for this chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 478081-98-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,0,8 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 478081-98:
(8*4)+(7*7)+(6*8)+(5*0)+(4*8)+(3*1)+(2*9)+(1*8)=190
190 % 10 = 0
So 478081-98-0 is a valid CAS Registry Number.
478081-98-0Relevant articles and documents
Synthetic studies connected with the preparation of N-[3-(3- cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide, a zaleplon regioisomer
Radl, Stanislav,Blahovcova, Michaela,Tkadlecova, Marcela,Havlicek, Jaroslav
scheme or table, p. 1359 - 1376 (2010/10/20)
N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethyl-acetamide, a principal impurity of zaleplon, is prepared by Suzuki-Miyaura cross coupling reaction of the corresponding boronic acid and/or boronates with 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile (7). Various methods of preparation of both components are described, as well as approaches based on the final modification of the 5-(3-aminophenyl)-pyrazolo[1,5-a]pyrimidine-3- carbonitrile moiety prepared by Suzuki-Miyaura cross coupling. All the prepared compounds were unambiguouesly identified by NMR techniques. Spectral characteristics (IR, UV, MS) of these compounds are also given.
Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
-
, (2008/06/13)
Zaleplon can be separated from a regioisomer impurity by crystallization from selected solvents or by adding an anti-solvent to a solution of zaleplon and the regioisomer. Zaleplon crystalline Forms II, III, IV, and V are useful for the treatment of insom
A PROCESS FOR THE PREPARATION OF ZALEPLON
-
Page 4; 5, (2008/06/13)
The invention relates to a process for the preparation of zaleplon (N-[3(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide) in the reaction of 3-dimethylamino-1-(3-N-ethyl-N-acetylaminophenyl)-2-propen-1-one with 3-aminopyrazole-4-carbonitril
