478082-99-4

Basic information

• Product Name: 1H-Indole, 7-(4-Methyl-1-piperazinyl)-3-(phenylsulfonyl)-
• Synonyms: 1H-Indole, 7-(4-Methyl-1-piperazinyl)-3-(phenylsulfonyl)-;3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)-1H-indole;7-(4-methyl-1-piperazinyl)-3-(phenylsulfonyl)-1H-Indole;Ro4368554
• CAS NO: 478082-99-4
• Molecular Formula: C19H21N3O2S
• Molecular Weight: 355.45394
• Mol File: 478082-99-4.mol
• Article Data: 1

Chemical Properties

• Appearance: off-white/
• Storage Temp.: room temp
• Solubility: DMSO: >10mg/mL
• CAS DataBase Reference: 1H-Indole, 7-(4-Methyl-1-piperazinyl)-3-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 7-(4-Methyl-1-piperazinyl)-3-(phenylsulfonyl)-(478082-99-4)
• EPA Substance Registry System: 1H-Indole, 7-(4-Methyl-1-piperazinyl)-3-(phenylsulfonyl)-(478082-99-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 2
• Hazardous Substances Data: 478082-99-4(Hazardous Substances Data)

Usage

Uses

Ro4368554 is a selective 5-Hydroxytryptamine 6 (5-HT6) receptor antagonists.

Biochem/physiol Actions

Ro4368554 is a 5-HT6 receptor antagonist. RO4368554 acts selectively at 5-HT6 receptors where it binds with a greater than 100-fold selectivity over other monoamine receptor subtypes (-log M pKi = 9.4 at 5-HT6 and 7.1 at 5-HT2A).

Relevant articles and documents

New indole derivatives with 5HT6 receptor affinity

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R5, R6 or R7 is a group of general Formula B, wherein W is a —CH— group or a nitrogen