478169-68-5

Basic information

• Product Name: Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate
• Synonyms: Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate;methyl 3-hydroxy-4-(2-(trimethylsilyl)ethynyl)benzoate
• CAS NO: 478169-68-5
• Molecular Formula: C₁₃H₁₆O₃Si
• Molecular Weight: 248.34984
• Mol File: 478169-68-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 332.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.10±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.80±0.40(Predicted)
• CAS DataBase Reference: Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate(478169-68-5)
• EPA Substance Registry System: Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate(478169-68-5)

Safety Data

• Hazardous Substances Data: 478169-68-5(Hazardous Substances Data)

Usage

General Description

Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate is a chemical compound with the molecular formula C13H16O3Si. It is a derivative of benzoic acid with a methyl ester group and a hydroxy group attached to the benzene ring. Additionally, it contains a trimethylsilyl group attached to the ethynyl group, which is a terminal alkyne. Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate is commonly used in organic synthesis as a building block for more complex molecules. Its unique structure and functional groups make it useful in the production of pharmaceuticals, agrochemicals, and other fine chemicals.

Upstream product

• 157942-12-6 methyl 3-hydroxy-4-iodobenzoate 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 588703-29-1 methyl benzofuran-6-carboxylate 
• 77095-51-3 benzofuran-6-carboxylic acid 
• 478169-69-6 methyl 3-hydroxy-4-acetyl-benzoate 
• 501892-53-1 N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]-1-benzofuran-6-carboxamide hydrochloride 

Relevant articles and documents

Synthesis method of 3-hydroxy-4-((trimethylsilyl) ethynyl) methyl benzoate

The invention relates to a synthetic method of 3-hydroxy-4-((trimethylsilyl) ethynyl) methyl benzoate, and belongs to the technical field of synthesis of medical intermediates. According to the method, 4-iodo-3-hydroxybenzoic acid and trimethylsilylacetyl

Azabicyclic compounds for the treatment of disease

The invention provides compounds of Formula I: 1wherein Azabicyclo is 2These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals in which α7 is known to be involved.

Substituted 7-aza[2.2.1]bicycloheptanes for the treatment of disease

The invention provides compounds of Formula I: which may be in the form of pharmaceutical acceptable salts or compositions, are useful in treating diseases or conditions in which α7 nicotinic acetylcholine receptors (nAChRs) are known to be involved.