478363-68-7Relevant articles and documents
1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8aβ)-6-isoquinolineamine derivatives, preparation method therefor and therapeutical use thereof
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, (2008/06/13)
1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8aβ)-isoquinolineamines of formula (I), wherein groups R1 -R3 are as defined in the description, a method for preparing same, and therapeutical uses thereof as agents for inhibiting the biosynthesis of cholesterol, particularly epoxysqualene cyclase, which are useful as cholesterol and lipid lowering drugs, antiatheromatic and antifungal agents.