47846-88-8

Basic information

• Product Name: Z-L-Lys(Boc)-L-Lys(Boc)-OH
• Synonyms: Z-L-Lys(Boc)-L-Lys(Boc)-OH
• CAS NO: 47846-88-8
• Molecular Weight: 608.733
• Mol File: 47846-88-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Z-L-Lys(Boc)-L-Lys(Boc)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-L-Lys(Boc)-L-Lys(Boc)-OH(47846-88-8)
• EPA Substance Registry System: Z-L-Lys(Boc)-L-Lys(Boc)-OH(47846-88-8)

Safety Data

• Hazardous Substances Data: 47846-88-8(Hazardous Substances Data)

Upstream product

• 50903-60-1 Z-L-Lys(BOC)-OPFP 
• 75481-36-6 N^ε-tert-butoxycarbonyllysine trimethylsilyl ester 
• 3338-34-9 Z-Lys(-Boc)-Osu 
• 2418-95-3 (S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid 
• 2389-60-8 Z-Lys(Boc)-OH 
• 23556-66-3 N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester 

Downstream Products

• 1616957-66-4 benzyloxycarbonyl-Lys-N-ε-(tert-butoxycarbonyl)-Lys-N-ε-(tert-butoxycarbonyl)-PABC-(7-amino-4-methylcoumarin) 
• 1616957-64-2 benzyloxycarbonyl-Lys-N-ε-(tert-butoxycarbonyl)-Lys-N-ε-(tert-butoxycarbonyl)-(p-aminobenzyl)-OH 
• 82774-91-2 Z-L-Val-Gly-L-Lys(BOC)-L-Lys(BOC)-OPFP 
• 7669-63-8 Z-L-Val-Gly-L-Lys(BOC)-L-Lys(BOC)-L-Arg(NO₂)-L-Arg(NO₂)-L-Pro-OH 
• 75481-38-8 N-benzyloxycarbonyl-L-valylglycyl-N^ε-tert-butoxycarbonyl-L-lysyl-N^ε-tert-butoxycarbonyl-L-lysine 

Relevant articles and documents

Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins

Cathepsin B (CTB) is a cysteine protease believed to be an important therapeutic target or biomarker for several diseases including aggressive cancer, arthritis, and parasitic infections. The development of probes capable of assessing CTB activity in cell lysates, living cells, and animal models of disease are needed to understand its role in disease progression. However, discovering probes selective to cathepsin B over other cysteine cathepsins is a significant challenge due to overlap of preferred substrates and binding site homology in this family of proteases. Herein we report the synthesis and detailed evaluation of two prodrug-inspired fluorogenic peptides designed to be efficient and selective substrate-based probes for CTB. Through cell lysate and cell assays, a promising lead candidate was identified that is efficiently processed and has high specificity for CTB over other cysteine cathepsins. This work represents a key step toward the design of rapid release prodrugs or substrate-based molecular imaging probes specific to CTB.

SYNTHESIS OF A MODIFIED FRAGMENT 13-19 OF THE SEQUENCE OF ACTH USING SILYL PROTECTION

A new scheme for the synthesis of a peptide representing a modified analog of fragments 13-19 of the sequence of the adrenocorticotropic hormone has been described, which uses a number of stages the trimethylsilyl grouping for the protection of the carbox