4792-57-8Relevant articles and documents
Rh(II)-catalyzed intramolecular annulation of N-sulfonyl 1,2,3-triazoles with indole derivatives: A new method for synthesis pyranoindoles
Xie, Hui,Yang, Jian-Xin,Bora, Pranjal Protim,Kang, Qiang
supporting information, p. 3014 - 3021 (2016/05/19)
A direct and highly stereoselective approach for the synthesis of Z-alkenyl-pyranoindoles had been developed by utilizing Rh(II)-catalyzed intramolecular cyclization of N-sulfonyl-1,2,3-triazoles with indole derivatives. A variety of pyranoindoles were obtained in 44-93% yields. Moreover, a more convenient synthesis of pyranoindoles starting from terminal alkyne was realized via a Cu-Rh sequentially catalyzed one-pot cascade reaction.
Process development of 5-methoxy-1H-indole-2-carboxylic acid from ethyl 2-methylmalonate
Bessard, Yves
, p. 214 - 220 (2013/09/08)
Development is described of a new process for the preparation from malonates of 5-methoxy-1H-indole-2-carboxylic acid esters, useful intermediates in the synthesis of pharmaceutical compounds. The process uses readily available starting materials, produces little waste, can be operated safely on at least 1 molar scale, and gives high yields. The main areas of optimization included the azo coupling of a diazonium salt with malonate derivatives, the Japp-Klingemann rearrangement, and the Fischer indole synthesis.