479622-22-5

Basic information

• Product Name: 3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: 3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 479622-22-5
• Molecular Weight: 388.464
• Mol File: 479622-22-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(479622-22-5)
• EPA Substance Registry System: 3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(479622-22-5)

Safety Data

• Hazardous Substances Data: 479622-22-5(Hazardous Substances Data)

Upstream product

• 1359824-26-2 C₂₇H₄₂N₂O₅Si 
• 114214-69-6 tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 5731-17-9 1-(Phenylmethyl)-3-pyrrolidinemethanol 
• 85310-69-6 pyrrolidin-3-ylmethanol 
• 479622-21-4 3-[1-(tert-butyl-dimethyl-silanyl)-2-carboxy-4-oxo-azetidin-3-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 479622-36-1 3-iodomethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 479622-23-6 (2S,3R)-3-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-pyrrolidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester 
• 727725-99-7 4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-pyrrolidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester 

Relevant articles and documents

Beta lactam compounds and their use as inhibitors of tryptase

Beta lactam compounds are provided which have the structure wherein B, A, D, R1, R2, R3 and X1 are as defined herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma and allergic rhinitis.

Synthesis of potent and highly selective inhibitors of human tryptase

The serine protease tryptase has been implicated in allergic and inflammatory diseases and associated with asthma. The synthesis and SAR of a series of N1-activated-4-carboxy azetidinones are described, resulting in identification of BMS-363131 (2) as a potent inhibitor of human tryptase (IC503000-fold) for tryptase versus related serine proteases including trypsin.