479623-43-3Relevant articles and documents
(S)-leucine and [(S)-1-(1-naphthyl)ethyl]amine as chiral building blocks for a bifunctional system - Synthesis of a new chiral stationary phase and evaluation of its biselector properties in the HPLC resolution of racemic compounds
Iuliano, Anna,Attolino, Emanuele,Salvadori, Piero
, p. 3523 - 3529 (2007/10/03)
Two selectors derived from [(S)-1-(1-naphthyl)ethyl]amine and (S)-leucine have been chemically bonded to one another and the resulting chiral auxiliary linked covalently to silica gel, to produce a new chiral stationary phase (CSP) for the HPLC resolution of enantiomers. The CSP is able to separate the enantiomers of some selected racemic compounds: both those resolved by Oi's CSP {derived from [1-(1-naphthyl)ethyl]amine} and those enantiodiscriminated by Pirkle's CSP [derived from N-(3,5-dinitrobenzoyl)leucine]. The results obtained demonstrate that the CSP possesses the properties of an efficient biselector system.