4798-75-8

Basic information

• Product Name: phenyl bis(2-chloroethyl)phosphoramidochloridate
• CAS NO: 4798-75-8
• Molecular Formula: C₁₀H₁₃Cl₃NO₂P
• Molecular Weight: 316.5485
• Mol File: 4798-75-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 385.5°C at 760 mmHg
• Flash Point: 186.9°C
• Density: 1.385g/cm³
• Vapor Pressure: 3.79E-06mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: phenyl bis(2-chloroethyl)phosphoramidochloridate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl bis(2-chloroethyl)phosphoramidochloridate(4798-75-8)
• EPA Substance Registry System: phenyl bis(2-chloroethyl)phosphoramidochloridate(4798-75-8)

Safety Data

• Hazardous Substances Data: 4798-75-8(Hazardous Substances Data)

Usage

General Description

Phenyl bis(2-chloroethyl)phosphoramidochloridate is a chemical compound that is commonly used as a reagent in the synthesis of organophosphorus compounds. It is a colorless to pale yellow liquid that is highly reactive and can be toxic when ingested, inhaled, or absorbed through the skin. phenyl bis(2-chloroethyl)phosphoramidochloridate is a member of the bis(2-chloroethyl)amino phosphoramidate family of chemicals, which are known for their use as precursors in the synthesis of chemical warfare agents. Due to its toxicity and potential for use in chemical weapons, phenyl bis(2-chloroethyl)phosphoramidochloridate is strictly regulated and controlled under international law.

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 
• 108-95-2 phenol 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 770-12-7 O-phenyl phosphorodichloridate 

Downstream Products

• 20464-96-4 N,N-bis-(2-chloro-ethyl)-P-morpholin-4-yl-phosphonamidic acid phenyl ester 
• 41423-53-4 N,N-bis-(2-chloro-ethyl)-N'-(4-methyl-thiazol-2-yl)-phosphorodiamidic acid phenyl ester 
• 41346-48-9 N,N-bis-(2-chloro-ethyl)-N'-(4-thiazol-2-ylsulfamoyl-phenyl)-phosphorodiamidic acid phenyl ester 
• 16012-71-8 C₂₀H₃₂Cl₂N₃O₄P 
• 78218-72-1 Phosphorsaeure-<2-chlor-ethylester>-phenylester- 
• 46779-96-8 N,N-bis(2-chloroethyl)phenylphosphoramidic acid 
• 100002-14-0 N,N,N',N'-Tetrakis-(2-chlorethyl)-symm.-pyrophosphorsaeure-diphenylester-diamid 
• 4798-76-9 Aziridin-phosphonsaeure-(1)-phenylester- 
• 98650-17-0 C₁₄H₂₃Cl₂N₂O₂P 
• 98650-19-2 C₁₂H₁₉Cl₂N₂O₂P 
• 81175-73-7 phenyl ester of N,N-bis(2-chloroethyl)-N',N'-bis(2-hydroxyethyl)diamidophosphoric acid 
• 98650-20-5 C₁₃H₂₁Cl₂N₂O₂P 
• 98650-21-6 C₁₄H₂₃Cl₂N₂O₂P 
• 131636-37-8 cyclopentamethyl phenyl N,N-bis(2-chloroethyl)phosphoramidate 

Relevant articles and documents

Novel sophoridine derivatives bearing phosphoramide mustard moiety exhibit potent antitumor activities in vitro and in vivo

Novel mustard functionalized sophoridine derivatives were synthesized and evaluated for their cytotoxicity against of a panel of various cancer cell lines. They were shown to be more sensitive to S180 and H22 tumor cells with IC50 values ranging from 1.01–3.65 μM, and distinctly were more cytotoxic to cancer cells than normal cell L929. In addition, compounds 7a, 7c, and 7e displayed moderate tumor suppression without apparent organ toxicity in vivo against mice bearing H22 liver tumors. Furthermore, they arrested tumor cells in the G1 phase and induced cellular apoptosis. Their potential binding modes with DNA-Top I complex have also been investigated.

Preparation method and use of quinolizidine alkaloid derivative

The invention provides a quinolizidine alkaloid derivative with high activity, low toxicity and good antitumor performance. The derivative is formed by merging a targeting quinolizidine alkaloid group and a highly-active chlormethine group in one molecule

Synthesis of ethyl and phenyl amido(ethoxyphenylalaninyl)phosphate compounds

The synthetic route for preparation of three phosphoramides containing amino acid and their precursors in good yield and mild conditions is reported. This involved the synthesis of the ethyl and phenyl phosphorodichloridate and its reaction with bis(β-chloroethyl) amine or diethylamine, followed by the reaction of the products with phenyl alanine ethyl ester hydrochloride. In all the three compounds, because of the presence of chiral centre, the final products were obtained as a mixture of two diastereoisomers, which can be determined using 31P NMR and TLC methods. The structures of all the prepared compounds were confirmed by 1H NMR, 31P NMR, 13C NMR spectroscopy.