4801-58-5

Basic information

• Product Name: 1-HYDROXYPIPERIDINE
• Synonyms: 1-HYDROXYPIPERIDINE;N-HYDROXYPIPERIDINE;1-hydroxy-piperidin;1-piperidinol;piperidin-1-ol;1-HYDROXYPIPERIDINE 96+%;1-HYDROXYPIPERDINE;1-Piperidinol/1-hydroxypiperidine
• CAS NO: 4801-58-5
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• EINECS: 225-362-9
• Product Categories: Building Blocks;C5 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines
• Mol File: 4801-58-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 37-39 °C
• Boiling Point: 146-148℃ (1 Torr)
• Flash Point: 78 °C
• Appearance: /
• Density: 0.9903 (rough estimate)
• Vapor Pressure: 0.542mmHg at 25°C
• Refractive Index: 1.4550 (estimate)
• Storage Temp.: 2-8°C
• PKA: 14.19±0.20(Predicted)
• BRN: 102726
• CAS DataBase Reference: 1-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXYPIPERIDINE(4801-58-5)
• EPA Substance Registry System: 1-HYDROXYPIPERIDINE(4801-58-5)

Safety Data

• WGK Germany: 3
• RTECS: TN6829550
• F: 3-10
• Hazardous Substances Data: 4801-58-5(Hazardous Substances Data)

Usage

Description

1-HYDROXYPIPERIDINE, also known as 1-piperidinol, is an organic compound with the chemical formula C5H11NO. It is a heterocyclic compound featuring a six-membered piperidine ring with a hydroxyl group attached to the first carbon. 1-HYDROXYPIPERIDINE is known for its solubility in water, organic solvents, aqueous acids, and bases, making it a versatile substance in various applications.

Uses

1. Used in Pharmaceutical Industry:
1-HYDROXYPIPERIDINE is used as a base for Fmoc-based solid phase peptide synthesis for its ability to facilitate the formation of peptide bonds in a controlled and efficient manner, which is crucial in the development of new drugs and therapies.
2. Used in Chemical Industry:
1-HYDROXYPIPERIDINE is used as a light stabilizing agent for its capacity to protect materials from the degrading effects of light exposure, thus enhancing the durability and longevity of products in various applications.
3. Used in Research and Development:
1-HYDROXYPIPERIDINE serves as an important intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals due to its unique chemical properties and reactivity.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5856, 1988 DOI: 10.1021/jo00260a012

InChI:InChI=1/C5H11NO/c7-6-4-2-1-3-5-6/h7H,1-5H2

Upstream product

• 110-89-4 piperidine 
• 4801-57-4 N-ethylpiperidine N-oxide 
• 93-59-4 Perbenzoic acid 
• 19653-33-9 ethyl piperidine-1-propionate 
• 766-09-6 1-ethyl-piperidine 
• 5542-49-4 piperidin-1-yl benzoate 
• 6635-57-0 1,5-pentanedioxime 
• 95650-50-3 5-(1-Oxy-piperidin-1-yl)-pentan-1-ol 
• 111-24-0 1,5-dibromo-pentane 
• 3088-41-3 3-(piperidin-1-yl)propionitrile 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 109-99-9 tetrahydrofuran 
• 4629-80-5 1,3-dimethyl-4-piperidinone 
• 109-72-8 n-butyllithium 

Downstream Products

• 4816-77-7 1-benzyloxycarbonyloxy-piperidine 
• 5868-64-4 N-Morpholinomethoxy-piperidin 
• 3515-13-7 diphenyl-(1-piperidin-1-yloxy-butoxy)-borane 
• 70546-85-9 2-phenyl-3,3a,4,5,6,7-hexahydro-2H-isoxazolo<2,3-a>pyridine 
• 70546-85-9 (2S,3aS)-2-Phenyl-hexahydro-isoxazolo[2,3-a]pyridine 
• 134721-10-1 trans-8-<2-(p-Benzyloxyphenyl)ethyl>-9-oxa-1-azabicyclo<4.3.0>nonane 
• 139883-70-8 (3R*,3aS*,9aS*,9bR*)-Octahydro-3-(2-benzyloxy)ethyl-1H-furo<3',4':4,5>isoxazolo<2,3-a>pyridin-1-one 
• 139883-70-8 (3S*,3aS*,9aS*,9bR*)-Octahydro-3-(2-benzyloxy)ethyl-1H-furo<3',4':4,5>isoxazolo<2,3-a>pyridin-1-one 
• 139883-70-8 (3S*,3aR*,9aS*,9bS*)-Octahydro-3-(2-benzyloxy)ethyl-1H-furo<3',4':4,5>isoxazolo<2,3-a>pyridin-1-one 
• 110-89-4 piperidine 
• 110-15-6 succinic acid 
• 84195-24-4 (S)-2-{(R)-6-Benzyloxycarbonylamino-2-[(R)-4-benzyloxycarbonyl-2-((S)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-butyrylamino]-hexanoylamino}-4-methyl-pentanoic acid piperidin-1-yl ester 
• 84215-04-3 C₆₅H₉₂N₈O₁₅ 
• 109253-33-0 1-benzhydryloxy-piperidine 

Relevant articles and documents

Selective Oxidation of Secondary Amines to N,N-Disubstituted Hydroxylamines by Choline Peroxydisulfate

N,N-Disubstituted hydroxylamines were prepared directly from secondary amines by a reliable method using an oxidizing task-specific ionic liquid, choline peroxydisulfate. The operational simplicity, high selectivity, and green reaction conditions, make this method efficient and practical.

Synthesis of N,N,O-Trisubstituted Hydroxylamines by Stepwise Reduction and Substitution of O-Acyl N,N-Disubstituted Hydroxylamines

Diverse N,N,O-trisubstituted hydroxylamines, an under-represented group in compound collections, are readily prepared by partial reduction of N-acyloxy secondary amines with diisobutylaluminum hydride followed by acetylation and reduction of the so-formed O-acyl-N,N-disubstituted hydroxylamines with triethylsilane and boron trifluoride etherate. Use of carbon nucleophiles in the last step, including allyltributylstannane, silyl enol ethers, and 2-methylfuran, gives N,N,O-trisubstituted hydroxylamines with branching α- to the O-substituent. N,N-Disubstiuted hydroxylamines are conveniently prepared by reaction of secondary amines with dibenzoyl peroxide followed by diisobutylaluminum hydride reduction.

Cyanine dyes

The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.