480449-84-1 Usage
Description
Cyclohexanecarboxylic acid, 4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester, (1S,3R,4S)is a complex organic compound with a specific stereochemistry. It is characterized by its unique molecular structure, which includes a cyclohexane ring, an amino group, and an ethyl ester group. Cyclohexanecarboxylic acid,
4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester,
(1S,3R,4S)is an important intermediate in the synthesis of various pharmaceuticals due to its versatile chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
Cyclohexanecarboxylic acid, 4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester, (1S,3R,4S)is used as an intermediate in the synthesis of Edoxaban-d6 (E555522), the isotope-labelled analog of Edoxaban (E555520). Edoxaban is an anticoagulant drug that acts as a direct factor Xa inhibitor, playing a crucial role in the prevention and treatment of blood clot-related disorders, such as deep vein thrombosis and pulmonary embolism.
In the synthesis of Edoxaban-d6, this compound serves as a key building block, contributing to the development of a drug with improved pharmacological properties, such as enhanced stability, better bioavailability, and potentially reduced side effects. The use of this compound in the pharmaceutical industry highlights its importance in the development of novel therapeutic agents and its potential impact on public health.
Check Digit Verification of cas no
The CAS Registry Mumber 480449-84-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,0,4,4 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 480449-84:
(8*4)+(7*8)+(6*0)+(5*4)+(4*4)+(3*9)+(2*8)+(1*4)=171
171 % 10 = 1
So 480449-84-1 is a valid CAS Registry Number.
480449-84-1Relevant articles and documents
Preparation method and intermediate of chiral diamine compound
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Paragraph 0040; 0041; 0042, (2019/07/04)
The present invention relates to a preparation method and an intermediate of a chiral diamine compound, wherein the chiral diamine compound is used for preparing the key intermediate of a small molecule oral anticoagulant edoxaban. According to the present invention, the steps of the preparation method of the chiral diamine compound 2 and the key intermediate 2B are defined in the specification, wherein the group R is preferably selected from methoxy, ethoxy and dimethylamino.
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa
Nagata, Tsutomu,Yoshino, Toshiharu,Haginoya, Noriyasu,Yoshikawa, Kenji,Nagamochi, Masatoshi,Kobayashi, Syozo,Komoriya, Satoshi,Yokomizo, Aki,Muto, Ryo,Yamaguchi, Mitsuhiro,Osanai, Ken,Suzuki, Makoto,Kanno, Hideyuki
experimental part, p. 1193 - 1206 (2009/08/08)
In the early 1990's, we reported on the low-molecular selective fXa inhibitor DX-9065a having two amidino groups. However, it had poor oral bioavailability due to its strong basic amidino groups. To obtain fXa inhibitors with improved oral bioavailability
Complete switch of product selectivity in asymmetric direct aldol reaction with two different chiral organocatalysts from a common chiral source
Nakayama, Keiji,Maruoka, Keiji
supporting information; experimental part, p. 17666 - 17667 (2009/06/23)
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