480996-61-0

Basic information

• Product Name: 2-(4-tolylamino)-9-tert-butoxycarbonyl-1,3-thiazino[6,5-b]indol-4-one
• Synonyms: 2-(4-tolylamino)-9-tert-butoxycarbonyl-1,3-thiazino[6,5-b]indol-4-one
• CAS NO: 480996-61-0
• Molecular Weight: 407.493
• Mol File: 480996-61-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-tolylamino)-9-tert-butoxycarbonyl-1,3-thiazino[6,5-b]indol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-tolylamino)-9-tert-butoxycarbonyl-1,3-thiazino[6,5-b]indol-4-one(480996-61-0)
• EPA Substance Registry System: 2-(4-tolylamino)-9-tert-butoxycarbonyl-1,3-thiazino[6,5-b]indol-4-one(480996-61-0)

Safety Data

• Hazardous Substances Data: 480996-61-0(Hazardous Substances Data)

Upstream product

• 377724-56-6 1-(tert-butoxycarbonyl)-2-chloroindol-3-ylcarbonyl isothiocyanate 
• 180922-71-8 1-(tert-butoxycarbonyl)-2-chloroindole-3-carboxaldehyde 
• 5059-30-3 2-chloroindole-3-carboxaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

A new approach to the synthesis of rare thiazino[6,5-b]indol-4-one derivatives. First total synthesis of the indole phytoalexin cyclobrassinon

The first synthesis of the indole phytoalexin cyclobrassinon and some of its analogues, possessing a thiazino[6,5-b]indol-4-one tricyclic ring system was performed starting from 1-substitued 2-chloroindole-3-carboxaldehydes. The route employed the intramolecular Et3N-mediated or photochemical nucleophilic substitution of a chlorine atom in the 2-position of the indole ring with a sulfur atom as a key step. Examination of biological activity against the selected tumor cell lines, bacteria and fungi revealed no expressive activity of synthesized compounds.