481-96-9 Usage
Description
Estradiol-3-sulfate, also known as estrone sulfate, is a steroid sulfate derived from the formal consensation of sulfuric acid with the hydroxy group of 17beta-estradiol. It is a biologically active metabolite of estradiol, which is a primary female sex hormone responsible for the regulation of the menstrual cycle, the development and regulation of the female reproductive system, and secondary sex characteristics.
Uses
Used in Pharmaceutical Industry:
Estradiol-3-sulfate is used as a hormone replacement therapy (HRT) for postmenopausal women to alleviate symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. It helps in maintaining bone density, reducing the risk of osteoporosis, and improving overall quality of life.
Used in Fertility Treatments:
In the field of reproductive medicine, estradiol-3-sulfate is used to support fertility treatments, such as in vitro fertilization (IVF) and intrauterine insemination (IUI). It plays a crucial role in the development of the endometrium, which is essential for successful implantation of the embryo.
Used in Hormone Research:
Estradiol-3-sulfate is used as a research tool in the study of hormone regulation, metabolism, and the development of new therapies for hormone-related disorders. It helps researchers understand the complex interactions between hormones and their target tissues, leading to the development of more effective treatments for various conditions.
Used in Diagnostics:
Estradiol-3-sulfate is used as a biomarker in the diagnosis and monitoring of certain conditions, such as polycystic ovary syndrome (PCOS) and other endocrine disorders. Measuring the levels of estradiol-3-sulfate in the blood can provide valuable information about a patient's hormonal status and help guide appropriate treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 481-96-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 481-96:
(5*4)+(4*8)+(3*1)+(2*9)+(1*6)=79
79 % 10 = 9
So 481-96-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H24O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,17+,18+/m1/s1
481-96-9Relevant articles and documents
Sulfation made easy: A new versatile donor for enzymatic sulfation by a bacterial arylsulfotransferase
Hartog, Aloysius F.,Wever, Ron
, p. 43 - 46 (2016)
An efficient and versatile donor for the sulfation by a bacterial arylsulfotransferase of various phenolic acceptor molecules is reported. Most studies in the past used toxic p-nitrophenyl sulfate as a sulfate donor for sulfation by this enzyme. However both the donor and p-nitrophenol are difficult to remove from the sulfated products. This new donor N-hydroxysuccinimide sulfate is easy to synthesize and has the advantage that at pH values above 7 it hydrolyzes to N-hydroxysuccinimide which is a safe compound and can easily be removed. As examples we demonstrated the formation of sulfated resveratrol and synthesized efficiently 3-sulfo-17-β-estradiol and bisphenol A bisulfate. It is likely that many other phenolic compounds are sulfated using this donor.
