48168-99-6

Basic information

• Product Name: L-Leucine, N-methyl-, phenylmethyl ester
• CAS NO: 48168-99-6
• Molecular Formula: C14H21NO2
• Molecular Weight: 235.326
• Mol File: 48168-99-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-methyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-methyl-, phenylmethyl ester(48168-99-6)
• EPA Substance Registry System: L-Leucine, N-methyl-, phenylmethyl ester(48168-99-6)

Safety Data

• Hazardous Substances Data: 48168-99-6(Hazardous Substances Data)

Usage

General Description

L-Leucine, N-methyl-, phenylmethyl ester is a chemical compound that is synthesized from the essential amino acid L-leucine. It is commonly used as a supplement in bodybuilding and fitness products due to its role in protein synthesis and muscle growth. L-Leucine, N-methyl-, phenylmethyl ester has been studied for its potential benefits in promoting muscle recovery and reducing muscle breakdown during exercise. Additionally, it has been suggested to have potential anti-catabolic and anabolic effects, making it a popular ingredient in sports nutrition supplements. However,

Upstream product

• 100-52-7 benzaldehyde 
• 1738-77-8 L-leucine benzyl ester p-toluenesulfonate 
• 53363-89-6 N-t-butoxycarbonyl-N-methyl-L-leucine 
• 61-90-5 L-leucine 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 3060-46-6 N-methyl-L-leucine 
• 100-51-6 benzyl alcohol 
• 175087-32-8 Boc-Leu(Me)-OBzl 
• 2016-04-8 N,N-dimethylformamide dibenzyl acetal 
• 421-20-5 Methyl fluorosulfonate 
• 80870-36-6 N-Benzyliden-(S)-leucin-benzylester 

Downstream Products

• 1298116-74-1 Fmoc-L-Leu(N-Me)-L-Leu(N-Me)-OBn 
• 93-91-4 1-phenylbutan-1,3-dione 
• 1021875-40-0 Boc-L-Leu-N-Me-L-Leu-OBn 
• 2900-41-6 O-Benzyloxycarbonyl-L-α-hydroxy-isovaleriansaeure-L-val-N-methyl-L-leu-benzylester 
• 743382-50-5 L-Valyl-N-methyl-L-leucin-benzylester 
• 81135-34-4 Boc-D-Ala-MeLeu-OBzl 
• 89537-08-6 Boc-MeLeu-MeLeu-MeVal-OBzl 
• 81135-36-6 Boc-D-Ala-MeLeu-MeLeu-OBzl 
• 89536-93-6 Boc-D-Ala-MeLeu-D-MeLeu-OBzl 
• 89537-09-7 H-MeLeu-MeLeu-MeVal-OBzl 
• 112550-37-5 N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol 
• 112550-36-4 N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol 

Relevant articles and documents

Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators

High blood pressure and consequential cardiovascular diseases are among the top causes of death worldwide. The apelinergic (APJ) system has emerged as a promising target for the treatment of cardiovascular issues, especially prevention of ischemia reperfusion (IR) injury after a heart attack or stroke. However, rapid degradation of the endogenous apelin peptides in vivo limits their use as therapeutic agents. Here, we study the effects of simple homologue substitutions, i.e. incorporation of non-canonical amino acids l-cyclohexylalanine (l-Cha) and l-homoarginine (l-hArg), on the proteolytic stability of pyr-1-apelin-13 and apelin-17 analogues. The modified 13-mers display up to 40 times longer plasma half-life than native apelin-13 and in preliminary in vivo assay show moderate blood pressure-lowering effects. The corresponding apelin-17 analogues show pronounced blood pressure-lowering effects and up to a 340-fold increase in plasma half-life compared to the native apelin-17 isoforms, suggesting their potential use in the design of metabolically stable apelin analogues to prevent IR injury. This journal is

Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors

The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, α- keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.

Synthesis of cyclosporine. Part II. Synthesis of Boc-D-Ala-MeLeu-MeLeu-MeVal-OH, a part of the peptide sequence of cyclosporine, by different strategic ways and synthesis of its isomers Boc-D-Ala-MeLeu-D-MeLeu-MeVal-OH, Boc-D-Ala-Meleu-D-MeLeu-D-MeVal-OH,

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