482-05-3

Basic information

• Product Name: Diphenic acid
• Synonyms: 2,2''-BIPHENYLDICARBOXYLIC ACID / DIPHENIC ACID;1,4,5,8-NAPHTHALENETETRACARBOXYLIC ACID,95.0%MIN;2,2'-Biphenyldicarboxylic acid;2-(2-Carboxyphenyl)benzoic acid;Diphenic acid,Biphenyl-2,2′-dicarboxylic acid;2,2-United acid;Diphenic acid, 96% 25GR;2,2'-Bibenzoic Acid 2,2'-Dicarboxybiphenyl Diphenic Acid
• CAS NO: 482-05-3
• Molecular Formula: C14H10O4
• Molecular Weight: 242.23
• EINECS: 207-576-4
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Biphenyl & Diphenyl ether;Biphenyls (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;Biphenyl series
• Mol File: 482-05-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 227-229 °C(lit.)
• Boiling Point: 345.05°C (rough estimate)
• Flash Point: 223.651 °C
• Appearance: Off-white powder
• Density: 1.2695 (rough estimate)
• Vapor Pressure: 6.65E-08mmHg at 25°C
• Refractive Index: 1.5389 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: almost transparency in Methanol
• PKA: pKa 3.20(H2O t=23.0) (Uncertain);5.06(H2O t=23.0) (Uncertain)
• Water Solubility: insoluble (20 ºC)
• Merck: 14,3310
• BRN: 2053625
• CAS DataBase Reference: Diphenic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Diphenic acid(482-05-3)
• EPA Substance Registry System: Diphenic acid(482-05-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 482-05-3(Hazardous Substances Data)

Usage

Description

Diphenic acid, also known as 2,2'Dicarboxybiphenyl acid, is a pharmaceutical intermediate with significant therapeutic properties. It is an off-white powder that has been found to lower the risk of chronic diseases such as cancer, cardiovascular diseases, and other pathologies. Diphenic acid derivatives are commonly found in fruits like blackberry, raspberry, and strawberry, making it a valuable component in the pharmaceutical and food industries.

Uses

Used in Pharmaceutical Industry:
Diphenic acid is used as a pharmaceutical intermediate for its potential in lowering the risk of chronic diseases. Its derivatives have shown great promise in the development of treatments for conditions such as cancer and cardiovascular diseases.
Used in Dye Synthesis:
Diphenic acid is used as a key component in the synthesis of dyes, contributing to its utility in the chemical industry.
Used in Herbal Medicine:
Diphenic acid is used in various herbs due to its therapeutic properties, making it a valuable addition to the field of herbal medicine.
Used in Food Industry:
Diphenic acid is used as a component in the food industry, particularly in fruits like blackberry, raspberry, and strawberry, where its presence contributes to the overall health benefits of these products.

Sources

https://www.alfa.com/zh-cn/catalog/A15863/ https://www.tandfonline.com/doi/abs/10.1080/00397911.2017.1298805?journalCode=lsyc20

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2876, 1960 DOI: 10.1021/ja01496a051Organic Syntheses, Coll. Vol. 1, p. 222, 1941Synthesis, p. 731, 1982

Purification Methods

Crystallise diphenic acid from water. Hot Ac2O provides the anhydride below. [Beilstein 9 H 922, 9 IV 3552.]

InChI:InChI=1/C14H10O4/c15-13(16)11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(17)18/h1-8H,(H,15,16)(H,17,18)/p-2