4820-07-9

Basic information

• Product Name: Benzene, 1-methyl-4-[(phenylmethyl)sulfinyl]-, (R)-
• CAS NO: 4820-07-9
• Molecular Formula: C14H14OS
• Molecular Weight: 230.331
• Mol File: 4820-07-9.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methyl-4-[(phenylmethyl)sulfinyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methyl-4-[(phenylmethyl)sulfinyl]-, (R)-(4820-07-9)
• EPA Substance Registry System: Benzene, 1-methyl-4-[(phenylmethyl)sulfinyl]-, (R)-(4820-07-9)

Safety Data

• Hazardous Substances Data: 4820-07-9(Hazardous Substances Data)

Upstream product

• 5023-60-9 1-benzylsulfanyl-4-methyl-benzene 
• 1517-82-4 (-)-menthyl p-toluenesulfinate 
• 6921-34-2 benzylmagnesium chloride 
• 921765-53-9 3-(phenylmethylsulfinyl)propionic acid tert-butyl ester 
• 624-31-7 4-tolyl iodide 
• 100-53-8 phenylmethanethiol 
• 106-45-6 para-thiocresol 
• 104-15-4 toluene-4-sulfonic acid 
• 100-44-7 benzyl chloride 
• 32018-21-6 2-[(4-methylphenyl)sulfanyl]ethyl phenyl sulfone 
• 1308833-65-9 1-methyl-4-[(2-(phenylsulfonyl)ethyl)sulfinyl]benzene 
• 100-39-0 benzyl bromide 
• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 10381-70-1 benzyl 4-methylphenyl sulfoxide 

Downstream Products

• 104891-17-0 (R)-3-Bromo-1-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-one 
• 104891-20-5 (S)-3-Bromo-1-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-one 
• 115879-08-8 (3R,R_S)-1-fluoro-3-<(4-methylphenyl)sulfinyl>-3-phenylpropan-2-one 
• 115879-11-3 (3S,R_S)-1-fluoro-3-<(4-methylphenyl)sulfinyl>-3-phenylpropan-2-one 
• 184636-31-5 (R)-2-Ethoxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester 
• 184636-30-4 (S)-2-Ethoxycarbonylamino-3,3,3-trifluoro-2-[(R)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-propionic acid methyl ester 
• 189396-88-1 (4-Methoxy-phenyl)-{(S)-2,2,2-trifluoro-1-[(S)-phenyl-((R)-toluene-4-sulfinyl)-methyl]-ethyl}-amine 

Relevant articles and documents

Chiral Ligands in Hypervalent Iodine Compounds: Synthesis and Structures of Binaphthyl-Based λ3-Iodanes

Several novel binaphthyl-based chiral hypervalent iodine(III) reagents have been prepared and structurally analysed. Various asymmetric oxidative reactions were applied to evaluate the reactivities and stereoselectivities of those reagents. Moderate to excellent yields were observed; however, very low stereoselectivities were obtained. NMR experiments indicated that these reagents are very easily hydrolysed in either chloroform or DMSO solvents leading to the limited stereoselectivities. It is concluded that the use of chiral ligands is an unsuccessful way to prepare efficient stereoselective iodine(III) reagents.

Palladium/PC-Phos-Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications

Herein we reported an efficient palladium-catalyzed enantioselective arylation of both alkyl and aryl sulfenate anions to deliver various chiral sulfoxides in good yields (up to 98%) with excellent enantioselectivities (up to 99% ee) by the use of our developed chiral O,P-ligands (PC-Phos). PC-Phos are easily prepared in short steps from inexpensive commercially available starting materials. The single-crystal structure of the PC4/PdCl2 showed that a rarely observed 11-membered ring was formed via the O,P-coordination with the palladium(II) center. The salient features of this method include general substrate scope, ease of scale-up, applicable to the late-stage modification of bioactive compounds, and the synthesis of a marketed medicine Sulindac.

Development of a Continuous-Flow Microreactor for Asymmetric Sulfoxidation Using a Biomimetic Manganese Catalyst

Asymmetric sulfoxidation catalyzed by a biomimetic manganese complex under continuous-flow microreactor is described. The reaction is conducted in microreactor, it can rapidly (4 min) oxidize a wide scope of sulfides with high yield (up to 91%) and excel