482580-70-1

Basic information

• Product Name: Benzene, 1,1'-[(3-nitropropoxy)methylene]bis-
• CAS NO: 482580-70-1
• Molecular Formula: C16H17NO3
• Molecular Weight: 271.316
• Mol File: 482580-70-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-[(3-nitropropoxy)methylene]bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-[(3-nitropropoxy)methylene]bis-(482580-70-1)
• EPA Substance Registry System: Benzene, 1,1'-[(3-nitropropoxy)methylene]bis-(482580-70-1)

Safety Data

• Hazardous Substances Data: 482580-70-1(Hazardous Substances Data)

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 25182-84-7 3-nitropropan-1-ol 

Downstream Products

• 482580-52-9 (S)-4-((Z)-4-Benzhydryloxy-2-nitro-but-1-enyl)-2,2-dimethyl-[1,3]dioxolane 
• 482580-34-7 4-Benzhydryloxy-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-2-one 
• 482580-66-5 4-Benzhydryloxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-nitro-butan-1-ol 

Relevant articles and documents

Chelation-controlled reduction: stereoselective formation of syn-1,3-diols and synthesis of compactin and mevinolin lactone.

Chelation-controlled reduction of chiral beta-alkoxy ketones containing a competing beta'-oxygen functionality has been investigated. Various syn-1,3-diols were prepared conveniently by reduction of beta-alkoxy ketones with LiI/LiAlH(4) (syn:anti selectivity up to >99:1). The corresponding beta-alkoxy ketones were derived from nitro-aldol reactions of chiral alkoxy aldehydes with a series of nitro compounds. This methodology is utilized in a short and efficient synthesis of the delta-lactone moiety of the HMG-CoA reductase inhibitors compactin and mevinolin.