4827-19-4 Usage
Description
(E)-1-(3-nitrophenyl)-2-phenyldiazene, also known as p-nitrophenylphenyldiazene, is a diazene compound with the molecular formula C12H9N3O2. It is a highly reactive and unstable compound that is used in the synthesis of azo dyes and organic pigments. It is a yellow to orange solid at room temperature and is known for its explosive nature. (E)-1-(3-nitrophenyl)-2-phenyldiazene is also used as a reagent in organic synthesis and its structure and properties make it a versatile compound in various chemical reactions and processes. However, it should be handled with caution due to its explosive nature and sensitivity to heat and shock.
Uses
Used in Chemical Synthesis:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as a reagent in the synthesis of azo dyes and organic pigments for [application reason] its ability to form a wide range of colored compounds that are useful in various industries.
Used in Research and Development:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as a research compound for [application reason] its unique structure and reactivity, which allows for the exploration of new chemical reactions and processes.
Used in Pharmaceutical Industry:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as an intermediate in the synthesis of certain pharmaceutical compounds for [application reason] its potential to be modified and incorporated into drug molecules.
Used in Dye and Pigment Industry:
(E)-1-(3-nitrophenyl)-2-phenyldiazene is used as a starting material for the production of azo dyes and organic pigments for [application reason] its ability to produce a variety of colors and its compatibility with different substrates.
Safety Precautions:
Due to the explosive nature and sensitivity to heat and shock of (E)-1-(3-nitrophenyl)-2-phenyldiazene, it should be handled with extreme caution in a controlled environment by trained professionals. Proper safety measures, including the use of protective equipment and adherence to safety protocols, should be in place to minimize the risk of accidents.
Check Digit Verification of cas no
The CAS Registry Mumber 4827-19-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,2 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4827-19:
(6*4)+(5*8)+(4*2)+(3*7)+(2*1)+(1*9)=104
104 % 10 = 4
So 4827-19-4 is a valid CAS Registry Number.
4827-19-4Relevant articles and documents
Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization
Luo, Jiajie,Qi, Hang,Qiao, Zhen,Tang, Xiaowen,Tang, Yi-Quan,Wang, KeWei,Wei, Ningning,Yin, Zhengji,Zhang, Yanru,Zhou, Qiqi,Zhu, Wei
supporting information, p. 16282 - 16292 (2021/11/12)
Transient receptor potential ankyrin 1 (TRPA1) channel, as a nonselective ligand-gated cation channel robustly in dorsal root ganglion sensory neurons, is implicated in sensing noxious stimuli and nociceptive signaling. However, small-molecule tools targeting TRPA1 lack temporal and spatial resolution, limiting their use for validation of TRPA1 as a therapeutic target for pain. In our previous work, we found that 4,4′-(diazene-1,2-diyl)dianiline (AB1) is a photoswitchable TRPA1 agonist, but the poor water solubility and activity hinder its further development. Here, we report a series of specific and potent azobenzene-derived photoswitchable TRPA1 agonists (series 1 and 2) that enable optical control of the TRPA1 channel. Two representative compounds 1g and 2c can alleviate capsaicin-induced pain in the cheek model of mice through channel desensitization but not in TRPA1 knockout mice. Taken together, our findings demonstrate that photoswitchable TRPA1 agonists can be used as pharmacological tools for study of pain signaling.
