484644-47-5

Basic information

• Product Name: N-[2-(4-chlorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]-N-cyclohexylamine
• Synonyms: N-[2-(4-chlorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]-N-cyclohexylamine
• CAS NO: 484644-47-5
• Molecular Weight: 339.868
• Mol File: 484644-47-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-[2-(4-chlorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]-N-cyclohexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-chlorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]-N-cyclohexylamine(484644-47-5)
• EPA Substance Registry System: N-[2-(4-chlorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]-N-cyclohexylamine(484644-47-5)

Safety Data

• Hazardous Substances Data: 484644-47-5(Hazardous Substances Data)

Upstream product

• 873-76-7 para-Chlorobenzyl alcohol 
• 1824-81-3 2-Amino-6-methylpyridine 
• 931-53-3 Cyclohexyl isocyanide 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Metal–organic framework of amine-MIL-53(Al) as active and reusable liquid-phase reaction inductor for multicomponent condensation of Ugi-type reactions

Metal–organic framework of NH2-MIL-53(Al), with coordinative unsaturated aluminium sites, has been shown to be active in the Groebke–Blackburn–Bienaymé multicomponent coupling reaction based on Ugi-type amine and aldehyde condensation over isocyanide and then a cyclization process. Interestingly this reaction occurred under solvent-free conditions with high yield, in which the NH2-MIL-53(Al) could be recovered and reused for five reaction cycles, giving a total turnover number of 455.

Three novel sequential reactions for the facile synthesis of a library of bisheterocycles possessing the 3-aminoimidazo[1,2- a ]pyridine core catalyzed by bismuth(III) chloride

Novel, one-pot, two-step, sequential protocols for the synthesis of 1,4-phenylene bisheterocyclic compounds have been developed. Successive sequencing of the Groebke-Blackburn-Bienaymé reaction with Ugi-azide, Hantzsch and Biginelli reactions results in rapid and efficient formation of bisheterocyclic compounds. A simple, fast and high yielding method for the synthesis of 3-aminoimidazo[1,2-a]pyridines catalyzed by bismuth(III) chloride under solvent-free conditions is reported. Bismuth(III) chloride is also an efficient catalyst for the Ugi-azide reaction under solvent free conditions. Georg Thieme Verlag Stuttgart - New York.

Nanomagnetically modified sulfuric acid (γ-Fe2O3@SiO2-OSO3H): An efficient, fast, and reusable green catalyst for the Ugi-like Groebke-Blackburn-Bienaymé three-component reaction under solvent-free conditions

Superparamagnetic nanoparticles of modified sulfuric acid (γ-Fe2O3@SiO2-OSO3H) represent a straightforward and green catalyst for the rapid synthesis of aminoimidazopyridine skeletons via the Ugi-like Groebke-Blackburn-Bienaymé three-component reaction. The γ-Fe2O3@SiO2-OSO3H catalyst could be recovered and reused in five reaction cycles, giving a total TON = 453. The products were prepared under solvent-free conditions without any additives.