484670-64-6Relevant articles and documents
A preparation of a macrocyclic lactone method
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Paragraph 0024; 0029; 0030, (2017/12/28)
The invention relates to a new preparation method of macrolides, belonging to the field of medicinal chemistry. The invention further relates to a preparation method of Solithromycin. The new preparation method comprises the following step of carrying out 7-th position saccharide ring removal, hydroxyl oxidation and reductive amination with a side chain to obtain an important intermediate (5) having a formula shown in the specification. The preparation method of Solithromycin, disclosed by the invention, has the advantages of few side reactions, operation simpleness and convenience, high yield and high suitability for industrial production. The structure of the intermediate (5) is as shown in the specification.
PROCESSES FOR PREPARING MACROLIDES AND KETOLIDES AND INTERMEDIATES THEREFOR
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, (2015/09/22)
The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes for preparing macrolides and ketolides from erythromycin A.
Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides
Hu, Lei,Lan, Ping,Song, Qiu-Ling,Huang, Zhi-Jian,Sun, Ping-Hua,Zhuo, Chao,Wang, Ying,Xiao, Shunian,Chen, Wei-Min
scheme or table, p. 5943 - 5949 (2011/01/13)
A series of C-12 pyrazolinyl spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-