4852-22-6 Usage
Description
Procyanidin is a novel, high-efficiency antioxidant and the most potent free radical scavenger discovered to date. It exhibits strong in vivo activity and is recognized for its various health-promoting properties.
Uses
Used in Pharmaceutical Applications:
Procyanidin is used as a therapeutic agent for improving blood circulation, treating diabetic retinopathy, reducing edema, and inhibiting varicose veins. Its potent antioxidant properties contribute to its effectiveness in these applications.
Used in Antioxidant Formulations:
Due to its strong free radical scavenging capabilities, Procyanidin is used as an antioxidant in various formulations to protect against oxidative stress and related health issues.
Used in Cosmetics:
Procyanidin's antioxidant properties also make it a valuable ingredient in the cosmetics industry, where it is used to protect the skin from environmental damage and promote overall skin health.
Chemical Properties:
Oligomeric procyanidin is readily soluble in polar solvents such as water, alcohol, ketone, glacial acetic acid, and ethyl acetate. However, it is insoluble in weak polar solvents like petroleum ether, chloroform, and benzene. Polymeric procyanidin is insoluble in hot water but can be dissolved in alcohol or sulfite solutions.
Pharmacology
Procyanidin can be rapidly absorbed in the gastrointestinal tract, reaching a peak value in 45min, with a half-life of 5h, 14% is excreted in bile within 11h, and 70% is excreted in the form of CO2, urine and feces after 24h, and is non-specifically bound in blood, liver and kidney. It binds specifically to the skin, blood vessel wall, and gastrointestinal mucosa, and is characterized by elevated levels of glucaminoglycans. Its main target organ is connective tissue, and its metabolism has an important entero-hepatic circulation.
Chemical Synthesis
At present, the commonly used process to synthesis?Procyanidin is to degreasing first, including squeezing method, solvent method, and supercritical CO2 extraction method. Among them, supercritical CO2 extraction method is the best, not only has high oil extraction rate, but also has the least destructive effect on proanthocyanidins, and the quality is relatively high.
Check Digit Verification of cas no
The CAS Registry Mumber 4852-22-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,5 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4852-22:
(6*4)+(5*8)+(4*5)+(3*2)+(2*2)+(1*2)=96
96 % 10 = 6
So 4852-22-6 is a valid CAS Registry Number.
InChI:InChI=1/C30H26O13/c31-14-7-19(35)16-11-25(28(41-23(16)9-14)12-1-3-17(33)20(36)5-12)43-30(13-2-4-18(34)21(37)6-13)29(40)27(39)26-22(38)8-15(32)10-24(26)42-30/h1-10,25,27-29,31-40H,11H2
4852-22-6Relevant articles and documents
Compositions containing proanthocyanidin and a vitamin B6 derivative or a salt thereof
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, (2008/06/13)
Proanthocyanidin-containing compositions with excellent proanthocyanidin stability, as well as drinks, foods, cosmetics and medicaments containing these compositions, are provided by admixing a vitamin B6derivative or its salt in proanthocyanidin. Also shown is a method for stabilizing proanthocyanidin to prevent its color change, etc. caused by oxidative polymerization and the like.
