485334-65-4

Basic information

• Product Name: [5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID
• Synonyms: AKOS TOT-0347;[5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID;ASINEX-REAG BAS 02531702;TIMTEC-BB SBB011981
• CAS NO: 485334-65-4
• Molecular Formula: C10H7FN2O3S
• Molecular Weight: 254.24
• Mol File: 485334-65-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 445.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• PKA: 2.84±0.10(Predicted)
• CAS DataBase Reference: [5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: [5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID(485334-65-4)
• EPA Substance Registry System: [5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID(485334-65-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 485334-65-4(Hazardous Substances Data)

Usage

Description

[5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID is a chemical compound with potentially significant pharmaceutical properties. It consists of a sulfur atom bonded to a 1,3,4-oxadiazol ring, which is connected to a phenyl group with a fluorine atom. The molecule also includes an acetic acid moiety. The combination of these elements suggests possible biological activities, such as anti-inflammatory or analgesic effects. Further research and testing are required to determine its full potential applications and impacts.

Uses

Used in Pharmaceutical Industry:
[5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID is used as a potential therapeutic agent for its possible anti-inflammatory or analgesic properties. The presence of the 1,3,4-oxadiazol ring, phenyl group with a fluorine atom, and the acetic acid moiety in the molecule may contribute to its potential effectiveness in treating various conditions related to inflammation and pain.
Used in Research and Development:
In the field of chemical research and development, [5-(4-FLUORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID serves as a valuable compound for further investigation. Its unique structure and potential biological activities make it an interesting candidate for exploring new drug development pathways and understanding its interactions with biological systems.

Upstream product

• 41421-13-0 2-mercapto-5-(4-fluorophenyl)-1,3,4-oxadiazole 
• 79-11-8 chloroacetic acid 
• 456-22-4 4-Fluorobenzoic acid 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 456-06-4 4-fluorobenzoyl hydrazide 

Relevant articles and documents

Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin–dioxazole combination as tubulin targeting anticancer agents

The advancement of cancer-fighting drugs has never been a simple linear process. Those drug design professionals begin to find inspiration from the nature after failing to find the ideal products by creative drug design and high-throughput screening. To obtain new molecules for inhibiting tubulin, podophyllotoxin was adopted as the leading compound and 1,3,4-oxadiazole was brought in to the C-4 site of podophyllotoxin in this research. A series of seventeen podophyllotoxin-derived esters have been achieved and then evaluated their antitumor activities against four different cancer cell lines: A549, MCF-7, HepG2, and HeLa. Among all the compounds, compound 7c showed the best antiproliferating properties with IC50?=?2.54?±?0.82?μm against MCF-7 cancer cell line. It was obvious that the content of ROS grew significantly in MCF-7 in a way depending on the dosage. The time- and dose-dependent cell cycle assays revealed that compound 7c could apparently block cell cycle in the phase of G2/M along with the upregulation of cyclin A2 and CDK2 protein. According to further studies, confocal microscopy experiment has certified that compound 7c could restrain cancer from growing by blocking the polymerization of microtubule. Meanwhile, compound 7c could be ideally integrated with the colchicine site of tubulin. In future, it would be feasible to selectively design tubulin inhibitors with the help of 3D-QSAR. This means that it is hopeful to develop compound 7c as a potential agent against cancer due to its biological characteristics.