485394-22-7

Basic information

• Product Name: bis-[2-((4S)-4-tert-butyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine
• CAS NO: 485394-22-7
• Molecular Weight: 419.567
• Mol File: 485394-22-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: bis-[2-((4S)-4-tert-butyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine(CAS DataBase Reference)
• NIST Chemistry Reference: bis-[2-((4S)-4-tert-butyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine(485394-22-7)
• EPA Substance Registry System: bis-[2-((4S)-4-tert-butyl-4,5-dihydro-oxazol-2-yl)-phenyl]-amine(485394-22-7)

Safety Data

• Hazardous Substances Data: 485394-22-7(Hazardous Substances Data)

Upstream product

• 154701-60-7 2-(2-bromophenyl)-4-(1,1-dimethylethyl)-4,5-dihydro-(4S)-oxazole 
• 194350-71-5 2-[(4S)-4-(tert-butyl)-4,5-dihydro-1,3-oxazol-2-yl]aniline 
• 1027046-68-9 Methanesulfonic acid (S)-2-{2-[2-((S)-1-methanesulfonyloxymethyl-2,2-dimethyl-propylcarbamoyl)-phenylamino]-benzoylamino}-3,3-dimethyl-butyl ester 
• 112245-13-3 (S)-tert-leucinol 
• 579-92-0 Vanadox 
• 815575-19-0 2,2'-bis[N-(1S)-(1-tert-butyl-2-hydroxyethyl)carbamoyl]diphenylamine 
• 118-48-9 isatoic anhydride 
• 485394-14-7 2-Amino-N-((S)-1-chloromethyl-2,2-dimethyl-propyl)-benzamide 
• 209850-70-4 N-[(1S)-1-hydroxymethyl-2,2-dimethylpropyl]-2-aminobenzamide 
• 32621-46-8 diphenylamine-2,2'-dicarbonyl chloride 

Relevant articles and documents

Cross-coupling of nonactivated primary and secondary alkyl halides with aryl Grignard reagents catalyzed by chiral iron pincer complexes

Iron(III) bisoxazolinylphenylamido (bopa) pincer complexes are efficient precatalysts for the cross-coupling of nonactivated primary and secondary alkyl halides with phenyl Grignard reagents. The reactions proceed at room temperature in moderate to excellent yields. A variety of functional groups can be tolerated. The enantioselectivity of the coupling of secondary alkyl halides is low.

Coupling of bulky, electron-deficient partners in aryl amination in the preparation of tridentate bis(oxazoline) ligands for asymmetric catalysis

A new class of tridentate bis(oxazoline) ligands 7, in which an N-phenylaniline unit links the two oxazoline rings, has been prepared. The key step in their synthesis is a Hartwig-Buchwald type Pd-catalyzed aryl amination between the two bulky o-substituted coupling partners, 2-(2′-bromophenyl)oxazolines 8 and 2-(o-aminophenyl)oxazolines 9. By varying the substituent on the coupling partners, a range of 10 ligands has been prepared in good yield. During the synthesis of 2-(o-aminophenyl)oxazolines 9a-d, a number of products of unexpected side reactions were isolated in two of the three steps. Alternatively, the required 2-(o-aminophenyl)oxazolines 9 were obtained by a DAST-promoted cyclodehydration of hydroxyamides 12a-d without formation of any byproducts.