486437-19-8

Basic information

• Product Name: 2-Propyn-1-amine, 3-[4-(trifluoromethyl)phenyl]-
• Synonyms: 3-(4-trifluoromethylphenyl)prop-2-ynylamine
• CAS NO: 486437-19-8
• Molecular Formula: C10H8F3N
• Molecular Weight: 199.175
• Mol File: 486437-19-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propyn-1-amine, 3-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-amine, 3-[4-(trifluoromethyl)phenyl]-(486437-19-8)
• EPA Substance Registry System: 2-Propyn-1-amine, 3-[4-(trifluoromethyl)phenyl]-(486437-19-8)

Safety Data

• Hazardous Substances Data: 486437-19-8(Hazardous Substances Data)

Upstream product

• 173546-21-9 3-(4-trifluoromethylphenyl)prop-2-yn-1-ol 
• 455-13-0 4-Iodobenzotrifluoride 

Downstream Products

• 486434-91-7 N-[3-(4-Trifluoromethylphenyl)-prop-2-ynyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide 
• 1313367-79-1 C₁₇H₂₂F₃N₃ 

Relevant articles and documents

Development of a telescoped flow process for the safe and effective generation of propargylic amines

Propargylic amines are important multifunctional building blocks that are frequently exploited in the synthesis of privileged heterocyclic entities. Herein we report on a novel flow process that achieves the safe and effective on-demand synthesis of propargylic amines in a telescoped manner. This process minimizes exposure to hazardous azide intermediates and renders a streamlined route into these building blocks. The value of this approach is demonstrated by the rapid generation of a small selection of drug-like thiazolines that result from a high-yielding reaction cascade between propargylic amines with different aryl isothiocyanates.