486460-08-6

Basic information

• Product Name: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE
• Synonyms: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE
• CAS NO: 486460-08-6
• Molecular Formula: C₁₅H₁₈F₃NO₄
• Molecular Weight: 333.3029296
• Mol File: 486460-08-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 405.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• PKA: 10.68±0.46(Predicted)
• CAS DataBase Reference: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE(486460-08-6)
• EPA Substance Registry System: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE(486460-08-6)

Safety Data

• Hazardous Substances Data: 486460-08-6(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 486460-07-5 (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine 
• 157911-56-3 2,4,5-trifluorobenzyl bromide 
• 1213132-66-1 methyl (R)-2-amino-3-(2,4,5-trifluorophenyl)propanoate 
• 121056-95-9 trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate 
• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 1500076-05-0 (Z)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)acrylate 

Downstream Products

• 486460-09-7 (R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 486460-25-7 [3-diazo-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 486460-32-6 sitagliptin 
• 1025950-29-1 [3-(5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-3-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1025933-74-7 [3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 486459-71-6 Sitagliptin hydrochloride 
• 1246221-03-3 (R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate 
• 1246221-01-1 C₁₅H₂₀F₃NO₅S 
• 1500076-07-2 (R)-tert-butyl (1-(4-phenyl-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate 
• 1500076-08-3 (R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate 
• 1500076-09-4 (R)-tert-butyl (1-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate 
• 1500076-10-7 (R)-tert-butyl (1-(5-phenyl-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate 

Relevant articles and documents

BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.