4866-61-9 Usage
Description
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(1H)-ONE, an organic compound with the molecular formula C6H5N5O, is a member of the pyrimidine derivatives class. It features a triazolopyrimidine core structure and is recognized for its potential pharmacological activities. This versatile chemical serves as a building block in the synthesis of various pharmaceuticals and is known for its antitumor, antiviral, and antimicrobial properties, making it a promising candidate for drug development.
Uses
Used in Pharmaceutical Industry:
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(1H)-ONE is used as a building block for the synthesis of various pharmaceuticals due to its potential pharmacological activities and versatile chemical structure.
Used in Antitumor Applications:
In the field of oncology, [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(1H)-ONE is used as an antitumor agent, contributing to the development of novel cancer treatments by targeting and inhibiting tumor growth.
Used in Antiviral Applications:
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(1H)-ONE is also utilized as an antiviral agent, showcasing its potential in the development of new antiviral drugs to combat viral infections.
Used in Antimicrobial Applications:
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(1H)-ONE is employed as an antimicrobial agent, indicating its potential use in the development of new antibiotics and antifungal medications to address the growing issue of antibiotic resistance.
Used in Neurological Disorder Treatment:
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(1H)-ONE has been studied for its potential use in the treatment of neurological disorders, suggesting its possible application in the development of medications targeting conditions such as Alzheimer's, Parkinson's, and epilepsy.
Used as an Analgesic Agent:
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7(1H)-ONE is also considered for its potential as an analgesic agent, which could lead to the development of new pain relief medications.
Check Digit Verification of cas no
The CAS Registry Mumber 4866-61-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,6 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4866-61:
(6*4)+(5*8)+(4*6)+(3*6)+(2*6)+(1*1)=119
119 % 10 = 9
So 4866-61-9 is a valid CAS Registry Number.
4866-61-9Relevant articles and documents
Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates
Heinrich, Timo,Buchstaller, Hans-Peter,Cezanne, Bertram,Rohdich, Felix,Bomke, J?rg,Friese-Hamim, Manja,Krier, Mireille,Kn?chel, Thorsten,Musil, Djordje,Leuthner, Birgitta,Zenke, Frank
, p. 551 - 556 (2017/01/17)
The natural product fumagillin 1 and derivatives like TNP-470 2 or beloranib 3 bind to methionine aminopeptidase 2 (MetAP-2) irreversibly. This enzyme is critical for protein maturation and plays a key role in angiogenesis. In this paper we describe the synthesis, MetAP-2 binding affinity and structural analysis of reversible MetAP-2 inhibitors. Optimization of enzymatic activity of screening hit 10 (IC50: 1?μM) led to the most potent compound 27 (IC50: 0.038?μM), with a concomitant improvement in LLE from 2.1 to 4.2. Structural analysis of these MetAP-2 inhibitors revealed an unprecedented conformation of the His339 side-chain imidazole ring being co-planar sandwiched between the imidazole of His331 and the aryl-ether moiety, which is bound to the purine scaffold. Systematic alteration and reduction of H-bonding capability of this metal binding moiety induced an unexpected 180° flip for the triazolo[1,5-a]pyrimdine bicyclic template.
NOVEL HETEROCYCLIC COMPOUNDS AS METAP-2 INHIBITORS
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Page/Page column 16-17, (2011/11/30)
Compounds of the formula I, in which D, X, Y, Z, R and R1 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
