4869-36-7

Basic information

• Product Name: 3(2H)-Pyridazinone, 6-(3,4-dimethylphenyl)-4,5-dihydro-
• CAS NO: 4869-36-7
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.256
• Mol File: 4869-36-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone, 6-(3,4-dimethylphenyl)-4,5-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 6-(3,4-dimethylphenyl)-4,5-dihydro-(4869-36-7)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 6-(3,4-dimethylphenyl)-4,5-dihydro-(4869-36-7)

Safety Data

• Hazardous Substances Data: 4869-36-7(Hazardous Substances Data)

Upstream product

• 86306-27-6 4-(3,4-dimethyl-phenyl)-4-oxo-butyric acid methyl ester 
• 51036-98-7 3-(3,4-dimethylbenzoyl)propionic acid 
• 95-47-6 o-xylene 

Relevant articles and documents

Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues

Pyridazinone analogues have been known to be potential candidates for anticonvulsant agents. We have identified several pyridazinone-based anticonvulsant agents. As a continuation to our previous research, a series of hybrid pyridazinone-thiazole connected through amide linkage were designed and synthesized. Among these, compound SP-5F demonstrated significant anticonvulsant activity with median effective dose of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Molecular docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of SP-5F.

Syntheses and antiinflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-pyridazinones

6-Aryl-2, 3, 4, 5-tetrahydro-3-pyridazinones (2c-22c) are obtained by dehydrocyclisation of various hydrazides formed by the reaction of appropriate methyl β-aroylpropionate and hydrazine hydrate in the presence of anhydrous sodium acetate. They show promising antiinflammatory activity during their evaluation by carrageenin induced paw edema test in rats.