487-80-9

Basic information

• Product Name: α-isokainic acid
• Synonyms: α-isokainic acid
• CAS NO: 487-80-9
• Molecular Weight: 213.233
• Mol File: 487-80-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-isokainic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-isokainic acid(487-80-9)
• EPA Substance Registry System: α-isokainic acid(487-80-9)

Safety Data

• Hazardous Substances Data: 487-80-9(Hazardous Substances Data)

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 10035-10-6 hydrogen bromide 
• 487-79-6 (-)-kainic acid 

Downstream Products

• 125292-93-5 [(3S)-2t-carboxy-4t-(α-hydroxy-isopropyl)-pyrrolidin-3r-yl]-acetic acid 

Relevant articles and documents

Synthesis of Kainoids and C4 Derivatives

A unified stereoselective synthesis of 4-substituted kainoids is reported. Four kainic acid analogues were obtained in 8-11 steps with up to 54% overall yields. Starting from trans-4-hydroxy-l-proline, the sequence enables a late-stage modification of C4 substituents with sp2 nucleophiles. Stereoselective steps include a cerium-promoted nucleophilic addition and a palladium-catalyzed reduction. A 10-step route to acid 21a was also established to enable ready functionalization of the C4 position.