4871-14-1

Basic information

• Product Name: 5-fluoro-1-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 1-Allyl-5-fluoropyrimidine-2,4(1H,3H)-dione; 2,4(1H,3H)-pyrimidinedione, 5-fluoro-1-(2-propen-1-yl)-
• CAS NO: 4871-14-1
• Molecular Formula: C₇H₇FN₂O₂
• Molecular Weight: 170.1411
• Mol File: 4871-14-1.mol
• Article Data: 10

Chemical Properties

• Density: 1.32g/cm³
• Refractive Index: 1.532
• CAS DataBase Reference: 5-fluoro-1-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-1-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione(4871-14-1)
• EPA Substance Registry System: 5-fluoro-1-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione(4871-14-1)

Safety Data

• Hazardous Substances Data: 4871-14-1(Hazardous Substances Data)

Upstream product

• 51-21-8 5-fluorouracil 
• 106-95-6 allyl bromide 
• 118004-30-1 Carbonic acid 3-allyl-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester benzyl ester 
• 17242-85-2 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine 
• 591-87-7 Allyl acetate 
• 107-18-6 allyl alcohol 

Downstream Products

• 877621-27-7 ethyl (3S,5R)-2-[5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-β-D-ribofuranosyl]-5-[(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]isoxazolidine-3-carboxylate 
• 877621-34-6 5-fluoro-1-({(3S,5R)-2-[5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-β-D-ribofuranosyl]-3-(hydroxymethyl)-1,2-isoxazolidin-5-yl}methyl)pyrimidine-2,4(1H,3H)-dione 
• 51-21-8 5-fluorouracil 

Relevant articles and documents

N-alkylated derivatives of 5-fluorouracil

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BIOORTHOGONAL METHODS AND COMPOUNDS

The invention provides a new bioorthogonal deprotection method for preparing heterocyclic compounds by bond cleavage using palladium. The methods have general application in the field of biological synthetic chemistry. Compounds, such as prodrugs, which are useful in such methods are also provided.

One-pot synthesis of N-alkyl purine and pyrimidine derivatives from alcohols using TsIm: a rapid entry into carboacyclic nucleoside synthesis

A convenient and efficient one-pot N-alkylation of nucleobases from alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of purine or pyrimidine nucleobase, TsIm, K2CO3, and triethylamine in refluxing DMF regioselectively furnishes the corresponding N-alkyl nucleobases in good yields. This methodology is highly efficient for various structurally diverse primary alcohols.