4874-17-3

Basic information

• Product Name: N~3~-methyl-beta-alaninamide(SALTDATA: HCl)
• Synonyms: N~3~-methyl-beta-alaninamide(SALTDATA: HCl);3-(Methylamino)propionamide, N-Methyl-beta-alanamide;3-(MethylaMino)propionaMide;3-(Methylamino)propionamide 95%
• CAS NO: 4874-17-3
• Molecular Formula: C₄H₁₀N₂O
• Molecular Weight: 102.135
• Mol File: 4874-17-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 274.5±23.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: /
• Density: 1.052 g/mL at 25 °C
• Refractive Index: n20/D1.485
• PKA: 16.43±0.40(Predicted)
• CAS DataBase Reference: N~3~-methyl-beta-alaninamide(SALTDATA: HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: N~3~-methyl-beta-alaninamide(SALTDATA: HCl)(4874-17-3)
• EPA Substance Registry System: N~3~-methyl-beta-alaninamide(SALTDATA: HCl)(4874-17-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 4874-17-3(Hazardous Substances Data)

Usage

General Description

N^3^-methyl-beta-alaninamide (SALTDATA: HCl) is a chemical compound that consists of the methylated form of beta-alaninamide, a derivative of the amino acid beta-alanine. N~3~-methyl-beta-alaninamide(SALTDATA: HCl), when combined with hydrochloric acid, forms a salt. It is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and compounds. N^3^-methyl-beta-alaninamide (SALTDATA: HCl) has potential applications in the treatment of various medical conditions, including neurodegenerative diseases and central nervous system disorders. It is important to handle this chemical with care, following appropriate safety protocols and guidelines to avoid any potential hazards.

Upstream product

• 5875-24-1 3-chloropropionamide 
• 74-89-5 methylamine 
• 693-05-0 N-(2-cyanoethyl)-N-methylamine 

Downstream Products

• 1307810-42-9 3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)amino)propanamide 

Relevant articles and documents

Synthesis of Ring-Opened Analogues of Oxysterol-Binding Protein-Inhibiting Piperidinyl-thiazole Fungicides

Novel aminoethyl-, aminopropyl-, and aminobutyl-substituted thiazole-4-carboxamides have been prepared which are ring-opened analogues of piperidinyl-thiazole fungicides. Depending of the chain length, completely different synthetic approaches had to be chosen which vary from a Sonogashira coupling with a 2-bromothiazole derivative to a thiazole ring construction from different β- and δ-amino acids.

Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia

[18F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide ([18F]-EF3) has been prepared, in 65% chemical yield and 5% radiochemical yield, by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate 1 with [18F]-3,3,3-trifluoropropylamine 7. This original radiolabelled key-synthon was obtained in 40% overall chemical yield by oxidative [18F]-fluorodesulfurization of ethyl N-phthalimido-3-aminopropane dithioate 4, followed by deprotection with hydrazine of the resulting [18F]-N-phthalimido-3,3,3-trifluoropropylamine 5. All the process was performed within 90min, from the [18F]-HF production in the cyclotron to the purification of the final target. Copyright