488713-31-1

Basic information

• Product Name: 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-
• Synonyms: 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-;5-AMino-3-chloropyridine-2-carbonitrile;5-amino-3-chloropicolinonitrile;5-Amino-3-chloro-2-cyanopyridine;5-Amino-3-chloro-2-pyridinecarbonitrile
• CAS NO: 488713-31-1
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.572
• Mol File: 488713-31-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 400.477 °C at 760 mmHg
• Flash Point: 196.001 °C
• Appearance: /
• Density: 1.427 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-(488713-31-1)
• EPA Substance Registry System: 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO-(488713-31-1)

Safety Data

• Hazardous Substances Data: 488713-31-1(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarbonitrile, 5-amino-3-chloro- is a chemical compound with the molecular formula C6H4ClN3. It is a derivative of pyridine and is commonly used in organic synthesis as an intermediate in the production of various pharmaceuticals and agrochemicals. 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- is also used as a building block in the synthesis of other heterocyclic compounds. It is an important chemical in the pharmaceutical industry and is used in the production of a wide range of drugs, including anti-inflammatory, anti-cancer, and antimicrobial agents. Additionally, it has applications in the production of dyes and pigments.

Upstream product

• 488713-30-0 3-chloro-5-nitropyridine-2-carbonitrile 
• 7439-89-6 iron 
• 22353-40-8 2,3-dichloro-5-nitropyridine 
• 488713-29-7 3-chloro-2-iodo-5-nitropyridine 
• 1186637-78-4 tert-butyl 5-chloro-6-cyanopyridin-3-ylcarbamate 
• 945557-04-0 5-bromo-3-chloro-pyridine-2-carbonitrile 

Relevant articles and documents

DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.

HETEROCYCLIC COMPOUND

The present invention provides a heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optinally having substituent(s), or a salt thereof.

Bicyclic modulators of androgen receptor function

The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.