488834-75-9 Usage
Description
(6-Hydroxymethyl)quinoxaline, also known as Quinoxalin-6-ylmethanol, is an organic compound with the molecular formula C9H8N2O2. It is a heterocyclic compound featuring a quinoxaline ring, which is a fused bicyclic structure consisting of a pyrazine and a pyridine ring. The presence of a hydroxymethyl group (-CH2OH) attached to the 6th position of the quinoxaline ring provides this compound with unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
(6-Hydroxymethyl)quinoxaline is used as a key intermediate for the synthesis of various quinoline and quinoxaline analogs of combretastatins. These analogs are of significant interest due to their potential applications in the development of novel anticancer drugs. Combretastatins are known for their ability to inhibit tumor angiogenesis, which is the formation of new blood vessels that supply nutrients to the tumor, thereby restricting its growth and metastasis.
Used in Chemical Research:
(6-Hydroxymethyl)quinoxaline can also be utilized as a building block in the synthesis of other complex organic molecules, particularly those containing the quinoxaline ring system. This makes it a valuable compound for researchers working in the fields of medicinal chemistry, materials science, and chemical biology, where the development of new molecules with specific biological activities or material properties is of great importance.
Check Digit Verification of cas no
The CAS Registry Mumber 488834-75-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,8,8,3 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 488834-75:
(8*4)+(7*8)+(6*8)+(5*8)+(4*3)+(3*4)+(2*7)+(1*5)=219
219 % 10 = 9
So 488834-75-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O/c12-6-7-1-2-8-9(5-7)11-4-3-10-8/h1-5,12H,6H2
488834-75-9Relevant articles and documents
Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation
Mielcke, Tania R.,Mascarello, Alessandra,Filippi-Chiela, Eduardo,Zanin, Rafael F.,Lenz, Guido,Leal, Paulo César,Chirardia, Louise D.,Yunes, Rosendo A.,Nunes, Ricardo J.,Battastini, Ana M.O.,Morrone, Fernanda B.,Campos, Maria M.
, p. 255 - 264 (2012/03/26)
Gliomas are the most common and devastating tumors of the central nervous system (CNS). Many pieces of evidence point out the relevance of natural compounds for cancer therapy and prevention, including chalcones. In the present study, eight synthetic quin
Methods for preparing 5- and 6-benzyl-functionalized quinoxalines
-
, (2008/06/13)
The present invention pertains to methods for preparing 5- and 6-benzyl functionalized quinoxalines. In a first embodiment, the method comprises contacting an aqueous suspension of a 5- and 6-halomethyl quinoxaline with a water-soluble nucleophile. In a second embodiment, the method comprises contacting a 5- and 6-halomethyl quinoxaline with an organic solvent-soluble nucleophile in an inert polar organic solvent. In a third embodiment, the method comprises contacting a 5- and 6-halomethyl quinoxaline in an organic solvent with an aqueous solution of a water-soluble nucleophile in the presence of a phase transfer catalyst.
