489-17-8

Basic information

• Product Name: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE
• Synonyms: BenzenesulfonaMide, 4-fluoro-2-Methyl-;5-Fluoro-2-sulphamoyltoluene, 2-(Aminosulphonyl)-5-fluorotoluene;4-FLUORO-2-METHYL-BENZENESULFONAMIDE;4-FLUORO-2-METHYLBENZENESULPHONAMIDE;Benzenesulfonamide, 4-fluoro-2-methyl- (9CI)
• CAS NO: 489-17-8
• Molecular Formula: C₇H₈FNO₂S
• Molecular Weight: 189.21
• Product Categories: SULFONAMIDE;Benzene series;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 489-17-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 180-184 °C(lit.)
• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 149.8 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 0.000252mmHg at 25°C
• Refractive Index: 1.545
• PKA: 10.09±0.60(Predicted)
• CAS DataBase Reference: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE(489-17-8)
• EPA Substance Registry System: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE(489-17-8)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 489-17-8(Hazardous Substances Data)

Usage

Description

4-Fluoro-2-methylbenzenesulfonamide is an organic compound with the molecular formula C7H8FNO2S. It is a derivative of benzenesulfonamide, featuring a fluorine atom at the 4-position and a methyl group at the 2-position. 4-FLUORO-2-METHYL-BENZENESULFONAMIDE serves as a key intermediate in the synthesis of various other organic compounds and has potential applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
4-Fluoro-2-methylbenzenesulfonamide is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows for the creation of new molecules with potential therapeutic properties.
Used in Chemical Industry:
In the chemical industry, 4-Fluoro-2-methylbenzenesulfonamide is utilized as a building block for the synthesis of a range of organic compounds, including:
1. 4-fluoro-2-methyl-N-phenylbenzenesulfonamide: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE is synthesized using 4-Fluoro-2-methylbenzenesulfonamide as a starting material, and it may have specific applications in the development of new drugs or chemical products.
2. 4-fluoro-2-methyl-N-(m-tolyl)benzenesulfonamide: Another derivative synthesized from 4-Fluoro-2-methylbenzenesulfonamide, this compound could be used in the creation of novel chemical entities with potential applications in various industries.
3. N-(3-chlorophenyl)-4-fluoro-2-methylbenzenesulfonamide: 4-FLUORO-2-METHYL-BENZENESULFONAMIDE, synthesized from 4-Fluoro-2-methylbenzenesulfonamide, may have specific uses in the development of new pharmaceuticals or other chemical products due to its unique structural features.
Overall, 4-Fluoro-2-methylbenzenesulfonamide plays a crucial role in the synthesis of various compounds, making it a valuable asset in both the pharmaceutical and chemical industries. Its applications are diverse, ranging from the development of new drugs to the creation of novel chemical products with potential uses in various sectors.

InChI:InChI=1/C7H8FNO2S/c1-5-4-6(8)2-3-7(5)12(9,10)11/h2-4H,1H3,(H2,9,10,11)

Upstream product

• 352-70-5 m-Fluorotoluene 
• 7079-48-3 4-fluoro-2-methylbenzene-1-sulphonyl chloride 

Downstream Products

• 29083-18-9 5-fluoro-1,1,3-trioxo-2,3-dihydrobenzo[d]isothiazine 
• 845644-47-5 1,1-dioxo-2,3-dihydrobenzo[d]isothiazol-5-yl fluoride 
• 882852-66-6 N-[(4-fluoro-2-methylphenyl)sulfonyl]cyclohexanecaboxamide 
• 1206137-27-0 4-fluoro-2-methyl-N-phenyl-benzenesulfonamide 
• 1206156-05-9 4-fluoro-2-methyl-N-m-tolyl-benzenesulfonamide 
• 1206111-19-4 N-(3-chloro-phenyl)-4-fluoro-2-methyl-benzenesulfonamide 
• 1130322-03-0 C₂₇H₂₁ClFN₅O₄S 
• 845823-04-3 4-fluoro-2-methylbenzenethiol 

Relevant articles and documents

Preparation method and medical application of benzisothiazole and benzothiophene

The invention discloses a preparation method and medical application of benzisothiazole and benzothiophene, and telates to the field of pharmaceutical chemistry. According to the invention, benzisothiazole and benzothiophene are the first type of HIF-2 agonists; compared with a compound M1001 found by the applicant in the earlier stage, the invention has better HIF-2 agonist activity, and has remarkable enhancement activity on expression of mRNA and protein of EPO, VGEF, Glut1, NDRG1 and the like at the downstream of HIF-2, so that the invention can be used for preparing drugs for treating and/or preventing chronic kidney diseases/chronic renal anemia, dyslipidemia and high cholesterol caused by abnormal expression of HIF-2; and the method has a good industrialization prospect.

Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation

A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substituti