4894-23-9

Basic information

• Product Name: 3,5-Diphenyl-2-isoxazoline
• Synonyms: 3,5-Diphenyl-2-isoxazoline;3,5-diphenyl-4,5-dihydro-1,2-oxazole
• CAS NO: 4894-23-9
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.2698
• Mol File: 4894-23-9.mol
• Article Data: 67

Chemical Properties

• Boiling Point: 351.4°Cat760mmHg
• Flash Point: 135.4°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 8.37E-05mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 3,5-Diphenyl-2-isoxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Diphenyl-2-isoxazoline(4894-23-9)
• EPA Substance Registry System: 3,5-Diphenyl-2-isoxazoline(4894-23-9)

Safety Data

• Hazardous Substances Data: 4894-23-9(Hazardous Substances Data)

Usage

General Description

3,5-Diphenyl-2-isoxazoline is a chemical compound with the molecular formula C15H11NO. It is an isoxazoline derivative, which is a type of heterocyclic compound containing a five-membered ring with oxygen and nitrogen atoms. 3,5-Diphenyl-2-isoxazoline is used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural and chemical properties. It has also been studied for its potential biological activities, including as an antiproliferative agent against cancer cells and as an anti-inflammatory agent. Additionally, 3,5-Diphenyl-2-isoxazoline has applications in material science, specifically in the development of advanced polymers and liquid crystals due to its ability to form stable and complex molecular structures. Overall, this compound has diverse potential applications in the fields of medicine, agriculture, and material science.

InChI:InChI=1/C15H13NO/c1-3-7-12(8-4-1)14-11-15(17-16-14)13-9-5-2-6-10-13/h1-10,15H,11H2

Upstream product

• 100-42-5 styrene 
• 873-67-6 benzonitrile oxide 
• 60-29-7 diethyl ether 
• 98-81-7 1-bromovinylbenzene 
• 32831-01-9 3-chloro-3-phenylpropiophenone 
• 384814-07-7 N,N'-bis-(3-oxo-1,3-diphenyl-propyl)-hydroxylamine 
• 94-41-7 benzalacetophenone 
• 698-16-8 benzohydroximoyl chloride 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 622-42-4 1-nitro-1-phenylmethane 
• 932-90-1 syn-benzaldehyde oxime 
• 20141-73-5 benzaldehyde oxime O-tributylstannyl ether 
• 108199-02-6 O-ethoxycarbonylbenzohydroximoyl chloride 
• 1138-48-3 cis-1,2-diphenylcyclopropane 

Downstream Products

• 36879-72-8 4,5-diphenyl-3-oxazoline 
• 2039-49-8 3,5-diphehylisoxazole 
• 5371-55-1 1-hydroxyimino-1,3-diphenylpropane 
• 25756-02-9 erythro-3-amino-1,3-diphenylpropanol 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 42052-51-7 3-hydroxy-1,3-diphenylpropan-1-one 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 94-41-7 benzalacetophenone 
• 13286-60-7 (±)-3-amino-1,3-diphenylpropan-1-ol 
• 13286-60-7 (±)-3-amino-1,3-diphenylpropan-1-ol 
• 4888-31-7 3-Acetoxy-3-phenyl-propionsaeure-anilid 
• 4198-15-6 3-hydroxy-N,3-diphenylpropanamide 
• 3056-73-3 N-phenylcinnamamide 

Relevant articles and documents

Gold-Catalyzed Cyclization/Intermolecular Methylene Transfer Sequence of O-Propargylic Oximes Derived from Glyoxylates

We successfully extended our gold-catalyzed skeletal rearrangement reaction of O -propargylic oximes through C=N bond cleavage to include substrates having an ester group on the oxime moiety, affording the corresponding 2-isoxazolines having an alkoxycarb

Aqueous phase preparation method of isoxazoline compound participating in vitamin E micro-micelle

The invention provides an aqueous phase synthesis method of the isoxazoline compound represented by the formula (III), wherein the benzaldehyde oxime represented by the formula (I) is a substrate, and the aqueous solution of the surfactant in the mass concentration 1 wt % - 5 wt % is N - chlorosuccinimide. Under the common action of the basic substance, the olefinic compound represented by the formula (II) is reacted 6 - 16h at room temperature, and the resulting reaction liquid is subjected to post-treatment to obtain the isoxazoline compound represented by the formula (III). Water serves as a reaction solvent, the use amount of the organic solvent is reduced, and zero emission of the solvent is realized.

Study of the Features of the Reaction of Arylcyclopropanes with Nitrozonium Ethyl Sulfate or Nitrozonium Tetrafluoroborate

Abstract: The reactions of diaryl-, aryl-, and alkyl–arylcyclopropanes with ethyl nitrite in the presence of sulfur trioxide and sulfur trioxide dioxane complex, as well as the reactions of 1-alkyl-2-arylcyclopropanes with NOBF4 were studied. It was found that the attack of the nitrosonium cation, accompanied by the formation of a benzyl carbocation, leads to the formation of isoxazolines. The introduction of bulky alkyl substituents into the cyclopropane ring changes the regioselectivity of nitrosation, favoring the attack of the electrophilic particle on the benzyl position and leading to the competitive formation of an alkyl carbocation. Depending on the structure of the alkyl substituent, both products of intramolecular heterocyclization accompanied by skeletal rearrangements and products formed with the participation of an external nucleophile are formed.